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Alpha-catenin in Tissue Morphogenesis, Organ Maintenance and Cancer

Valera Vasioukhin
Associate Member
Fred Hutchinson Cancer Research Center

Wednesday, November 18, 2009 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Ray Monnat

Why Attend?
Cadherin-catenin-mediated intercellular adhesion is necessary for the assembly of individual cells into multicellular organisms. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are also linked to several major developmental signaling pathways. This seminar will discuss our findings on the role and mechanisms of alpha-catenin in mammalian tissue morphogenesis, organ maintenance and cancer.

Evidence Based Management of Liver Cancer: Integration of Research and Clinical Decision Making

Jordi Bruix, M.D.
Associate Professor
Director, Liver Cancer Group
University of Barcelona

Wednesday, December 2, 2009 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Jean Campbell

Why Attend?
Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related death and its incidence is growing worldwide. Treatment of HCC, particularly, the advanced stage disease, is limited and not curative. The combination of these factors has fueled a growing interest in this disease priming research in both its pathogenesis and clinical management. Dr. Jordi Bruix, leader of the Barcelona Clinic Liver Cancer (BCLC) group at the University of Barcelona, has made key contributions in both areas, with a major emphasis on the development of criteria that allow an evidence-based management from diagnosis to therapy. In addition, Dr. Bruix's group through several international collaborations has provided new insight into the molecular profiling of this neoplasm.

Dr. Bruix will discuss his recent work with the phase 3 sorafenib "SHARP" trial, the first successful treatment of advanced-stage HCC and share his critical insight on the implications of recent studies translational studies on the future of HCC research and clinical practice.

Nuclear Architecture and Aging

Tom Misteli, Ph.D.
Senior Investigator
Cell Biology of Genomes
National Cancer Institute, NIH

Wednesday, December 9, 2009 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Chuck Murry

Why Attend?
Who doesn't care, and at times worry, about aging? Yet, the molecular basis of human aging is one of the least understood fundamental biological processes. A multitude of diverse mechanisms and pathways have been suggested to cause aging. While aging can be readily experimentally studied using animal models, the mechanisms of human aging are more difficult to ascertain. A promising approach is the molecular and cellular interrogation of naturally occurring human pre-mature aging disorders. The most severe premature aging disease is Hutchinson-Gilford Progeria Syndrome. Remarkably, this disease is caused by mutations in a gene encoding major architectural proteins of the cell nucleus. We have analyzed the causes of cellular and organismal defects in this disease and shown that the HGPS mechanisms are also relevant for normal aging. The insights form this rare human disease reveals an intricate interplay between nuclear architecture, stem cell biology and aging.

Tom Misteli is a Senior Investigator at the National Cancer Institute, NIH. He has pioneered the field of genome cell biology by developing imaging approaches to study genomes and gene expression in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous international awards. He is the Editor-in-Chief of The Journal of Cell Biology and of Current Opinion in Cell Biology.

Stimulating Myocardial Regeneration with Cardiomyocyte Proliferation Factors

Bernhard Kuhn, M.D.
Associate Professor
Department of Cardiology
Children's Hospital Boston

Wednesday, December 16, 2009 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Chuck Murry

Why Attend?
Dr. Bernhard Kuhn is a physician-scientist with special interests in cardiac regeneration. He received his medical and graduate degrees from the Freie Universitat in Berlin, Germany, in 1999. Dr. Kuhn completed a residency in pediatrics at Yale in 2002 and a clinical and research fellowship in pediatric cardiology at Children's Hospital Boston in 2007. He is Assistant Professor of Pediatrics at Harvard Medical School. Dr. Kuhn's honors include the Young Investigator Award of the American College of Cardiology (Pathology and Physiology) in 2007.

Dr. Kuhn's laboratory at Children's Hospital Boston studies the mechanisms of heart muscle cell proliferation during development and in adult life with the goal of stimulating this process for treating heart failure. Researchers in Dr. Kuhn's laboratory have extensively studied two extracellular factors that stimulate heart muscle cell proliferation and promote heart muscle regeneration: a peptide of periostin, a component of the extracellular matrix, and neuregulin1, a growth factor. Dr. Kuhn's research may provide new regenerative strategies for the treatment of heart failure.

Presentation Title TBA

Janet Eary, M.D.
Associate Professor
Department of Nuclear Medicine
University of Washington

Wednesday, January 6, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Ray Monnat

Presentation Title TBA

Patrick Paddison, Ph.D.
Assistant Member
Human Biology Division
Fred Hutchinson Cancer Research Center

Wednesday, January 13, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Ray Monnat

Presentation Title TBA

Carla Grandori and Tom Martins
Research Associate Professors
UW Medicine Pharmacology

Wednesday, January 20, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Ray Monnat

Presentation Title TBA

Rachel Wong
Professor
Department of Biological Structure
University of Washington

Wednesday, January 27, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Suzy Dintzis

Presentation Title TBA

Georg Seelig
Quantitative Biology and DNA Nanotechnology
UW Electrical Engineering

Wednesday, February 3, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Ray Monnat

Presentation Title TBA

Mary-Claire King
Professor
Medical Genetics & Genome Sciences
University of Washington

Wednesday, February 10, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Chuck Murry

Presentation Title TBA

Brad Cookson
Professor
Laboratory Medicine & Microbiology
University of Washington

Wednesday, February 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Chuck Murry

Presentation Title TBA

Russ Van Gelder, M.D., Ph.D.
Professor and Chair
UW Medicine Ophthalmology

Wednesday, March 17, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Chuck Murry

Presentation Title TBA

Gwenn Garden
Associate Professor
UW Medicine Neurology

Wednesday, March 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Tom Montine

Presentation Title TBA

Michael Schuffler
Professor
UW Medicine Gastroenterology

Wednesday, April 7, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Melissa Upton

Presentation Title TBA

Ian Lipkin, M.D.
Professor
Departments of Epidemiology, Neurology and Pathology
Columbia University Medical Center

Wednesday, April 14, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Michael Linden

Presentation Title TBA

Kevin Roth, M.D., Ph.D.
Professor
Department of Pathology
University of Alabama at Birmingham

Wednesday, April 21, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Chuck Murry

Presentation Title TBA

Tueng Shen
Associate Professor
UW Medicine Ophthalmology/Bioengineering

Wednesday, May 12, 2010 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Chuck Murry

Merkel Cell Carcinoma and a New Polyomavirus: Mechanisms of Immune Escape by an Often-lethal Skin Malignancy

Paul Nghiem, M.D., Ph.D.
Associate Professor
UW Medicine Dermatology and Pathology

Wednesday, November 4, 2009 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Suzy Dintzis

Why Attend?
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with advanced age, UV exposure and a new human polyomavirus (integrated in 80% of MCCs). Although 10% of MCC patients are profoundly immune suppressed, 90% have apparently normal immunity. Using genome-wide studies of MCC tumors, we found clues as to immune evasion mechanisms in use by this cancer and associated with outcomes. Using IHC studies on validation sets, we have found evidence of profound intra-tumoral immune suppression in many cases associated with poor outcomes. In contrast, outcomes are excellent in cases with evidence of immune recognition of this tumor. These insights are leading to potential new prognostic tests and translational studies designed to activate immune recognition of this highly antigenic tumor that is currently lethal in about 40% of cases.

Paul Nghiem received his undergraduate degree from Harvard, MD & PhD from Stanford, trained in medicine (Brigham & Women's), dermatology (MGH) and post-doctoral fellowship (Stuart Schreiber's lab in Harvard Chemistry). He moved to Seattle in 2006 and is an Associate Professor of Medicine/Dermatology and Pathology (Adjunct) at UW, and Affiliate Investigator at Fred Hutchinson. He sees patients at the Seattle Cancer Care Alliance and his research lab is at SLU.

The Amazing Liver: New Perspectives on Regeneration and Cancer

Nelson Fausto, M.D.
Professor and Chair
UW Medicine Pathology

Wednesday, October 21, 2009 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Chuck Murry

Why Attend?
Most amphibians and fish can regenerate body parts, but mammals have lost this capacity. A question to be asked is "if they can do it, why cant we." Although we do not have clear answers to this question, the liver is a "yes we can" exception. The mechanisms of liver regeneration in mice and humans are complex and involve an initial priming phase in which hepatocytes respond to components of the innate immune system, enter the cell cycle and become sensitive to the effect of growth factors. In a second phase, hepatocytes progress through the cell cycle under growth factor stimulation, and after passing a restriction point, no longer require external proliferative stimuli. Understanding the cellular and molecular mechanisms of liver regeneration is important both because of its scientific interest but also because it has direct applicability to clinical practice, particularly in liver transplantation. Remarkably, liver regeneration even if repeated does not lead to carcinogenesis. New findings on liver cancer show that the liver stroma plays an essential role in the development of liver tumors, through the regulation of angiogenesis and the production of growth factors required for hepatocyte replication. Cancer development involves the close interaction between the stroma and hepatocytes.

MicroRNAs as Blood-based Cancer Biomarkers

Muneesh Tewari, MD, PhD
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center

Wednesday, June 3, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Ray Monnat, M.D.

Why Attend?
MicroRNAs are small (~22 nt) non-protein-encoding RNAs that regulate target messenger RNAs via sequence-specific base-pairing interactions. MicroRNAs play important roles in diverse biological contexts and disease states. In cancer tissues, alterations in microRNA expression have been shown to be useful biomarkers for disease classification and prognosis. Recently, microRNAs were found to be released by tumor cells into the blood in a cell-free form where they may be useful as blood-based biomarkers for cancer and potentially other diseases. Dr. Tewari will discuss these results and ongoing work in his lab on circulating microRNAs as potential blood-based biomarkers for human cancer.

Dr. Tewari earned a B.A. in Biochemistry from Case Western Reserve University and M.D. and Ph.D. degrees from the University of Michigan. After completing clinical training in Internal Medicine and Medical Oncology, he pursued postdoctoral training in systems biology of genetic and protein interaction networks at Dana-Farber Cancer Institute and Harvard Medical School. Since 2005 he has been on the faculty at the Fred Hutchinson Cancer Research Center, where he is currently an Assistant Member in the Human Biology and Clinical Research Divisions.

Pancreatic Cancer: Genes to Patients

Ralph Hruban, MD
Professor
Pathology/Oncology
John Hopkins University

Wednesday, May 27, 2009 - 4:30 PM
Health Science Center, K-069

Faculty Sponsor: Ray Monnat, M.D.

Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. Dr. Hruban has been a leader in integrating clinico-pathologic and molecular analyses of human cancer with a special interest in pancreatic carcinoma. Dr. Hruban's research over the past decade has focused on identifying specific genes, mutations and epigenetic profiles that may be determinants of pancreatic cancer risk and progression, and may provide novel insights to improve cancer diagnosis and therapy. His talk will focus on integrating these new data to improve the care of individuals with pancreatic cancer and their families.

Ralph H. Hruban is a Professor of Pathology and Oncology at The Johns Hopkins University School of Medicine. He received his M.D. and completed Residency training at Johns Hopkins, did Fellowship training at Memorial Sloan-Kettering Cancer Center in New York and then returned to Baltimore to join the Johns Hopkins faculty in 1990. Dr. Hruban is currently the Director of The Sol Goldman Pancreatic Cancer Research Center, and Director of the Division of Gastrointestinal/Liver Pathology at Johns Hopkins. In addition to his research Dr. Hruban helped create the Johns Hopkins Pancreatic Cancer Web site (http://pathology.jhu.edu/pancreas), serves on the Scientific Advisory Board of PanCAN and is a Board member or Director at the Monastra, Rolfe and Lustgarten Foundations that are all focused on pancreatic cancer.

Improving Cancer Gene Therapy: Molecular Evolution and the Search for Super Suicide Genes

Margaret Black, Ph.D.
Associate Professor
Pharmaceutical Sciences
Washington State University

Wednesday, May 20, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Larry Loeb, M.D., Ph.D.

Why Attend?
Suicide gene therapy employs nucleotide metabolizing enzymes to convert prodrugs to cytotoxic agents as a means to localize toxicity to tumors. Several enzymes involved in pyrimidine and purine anabolism are being exploited as suicide enzymes in combination with pharmacologically relevant analogs. The poor activity the enzymes display towards their respective prodrugs limits the overall therapeutic potential of suicide gene therapy. Dr. Black will discuss molecular engineering methods her lab is using to achieve a more potent cancer cell killing effect.

Dr. Black earned a B.A. in Biology from the University of California, Santa Cruz, and a M.A. in Microbiology from the University of California, Davis and a Ph.D. in Microbiology from Oregon State University. After completion of a postdoctoral fellowship at the University of Washington, she worked at Darwin Molecular Corp. for several years. Since 1998 she has been on the faculty at Washington State University (WSU) in the Department of Pharmaceutical Sciences. Dr. Black is currently the J. Roberts and Marcia Fosberg Distinguished Professor of Pharmacy and is Director of the Pharmacology/Toxicology Graduate Program at WSU.

Signaling Networks in Vascular Morphogenesis and Homeostasis

Luisa Iruela-Arispe, PhD
Professor
Molecular, Cell and Developmental Biology
UCLA

Wednesday, May 13, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Charles Murry, M.D., Ph.D.

Why Attend?
Our understanding of vascular fibrosis is limited, particularly at the molecular level. This seminar will discuss how specific molecular alterations in the tunica media result in progressive loss of smooth muscle, expansion of the tunica adventitia and vascular fibrosis. Luisa Iruela-Arispe is currently Professor in the Department of Molecular, Cell and Developmental Biology. She earned her Ph.D. in 1989 from the University of Sao Paulo in Brazil in 1989, but performed her thesis in Dr. Helene Sage at the University of Washington (Dept. of Biological Structure). She continued with Dr. Sage to complete post-doctoral training for four additional years. In 1994, she became Assistant Professor in the Department of Pathology at Harvard Medical School in 1994 and four years later she moved to UCLA, where she is today. Her research focuses on vascular development and pathology.

Mitochondrial Signaling and Dynamics in Health and Disease

Gyorgy Hajnoczky, PhD
Professor
Pathology, Anatomy & Cell Biology
Jefferson Medical University

Wednesday, May 6, 2009 - 4:30 PM
Health Sciences Center , K-069

Faculty Sponsor: Charles Murry, M.D., Ph.D.

Why Attend?
Emerging evidence supports the broad involvement of mitochondria in cell signaling and dynamics. These functions often depend on mitochondrial sensing and responding to calcium. Mitochondrial calcium uptake controls mitochondrial function and cell signaling, while excessive mitochondrial calcium accumulation has been implicated in various diseases.

Gyorgy Hajnoczky is currently a Professor in the Department of Pathology and Cell Biology at Thomas Jefferson University. He earned his M.D. (1987) and Ph.D. (1993) from Semmelweis Medical University in Hungary. In 1991, he joined the lab of Dr. Andrew Thomas at Thomas Jefferson University as a postdoc. He became an independent investigator and was appointed to Assistant Professor in 1995 and to full Professor in 2002. His research focuses on calcium and mitochondrial biology.

Prognostic & Predictive Factors in Surgical Patholgy - - A Critical Assessment

Mark Wick, MD
Professor
Pathology
Univeristy of Virginia

Friday, May 1, 2009 - 4:30 PM
Health Sciences Center, T-639

Faculty Sponsor: Matthew Yeh, M.D., Ph.D.

Why Attend?
Anatomic pathologists are increasingly being asked to evaluate tissue specimens for a growing number of biologically-relevant genes and gene products. These markers are thought to have importance in either prognosis or choice of therapy. However, relatively little attention has been given to the laboratory control mechanisms for assuring the validity of such analyses, and misconceptions also exist as to how they should be applied. This talk considers those issues.

Deciphering the Hereditary Prion Protein Amyloidoses

Bernardino Ghetti, MD
Professor
Pathology & Lab Medicine
Indiana University

Wednesday, April 22, 2009 - 4:30 PM
Health Science Center, K-069

Faculty Sponsor: Montine

7th Annual Alvord Lecture in Neuropathology

The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002.

Cellular and Molecular Biology of Natural Killer Cells: From Basic Science to Clinical Implications. A Personal Perspective

Vinay Kumar, MD, PhD
Professor and Chairman
Pathology
University of Chicago Medical School

Wednesday, April 15, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: UW Medicine Pathology Residents

Why Attend?
Dr Vinay Kumar is the Alice Hogge and Arthur Baer Professor, Chairman of the department of Pathology, and the Executive Vice Dean of the Biologic Sciences Division and Pritzker School of Medicine at the University of Chicago. After completing his medical training in India he completed a combined residency-PhD program at The All India Institute Medical Sciences, New Delhi. Soon thereafter, in 1972, he joined the department of pathology at Boston University School of Medicine, then chaired by Dr Stanley Robbins. In 1982, he moved to UT Southwestern Medical School in Dallas where he was appointed Vernie Stembridge Professor of Pathology in 1992. In 2000 he moved to the University of Chicago to chair the department of Pathology and was named the Executive Vice Dean in 2007.

Dr Kumar has devoted his career to medical education and basic research in immunology. He is the coauthor of Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology, and is currently the senior editor/author of both. These two texts with dozens of translations are the most widely used texts of Pathology worldwide. In 1974, two years after he joined Boston University, he and his colleagues discovered a new class of lymphocytes, later called NK cells, as mediators of resistance to acute leukemia in mice. Since then his laboratory has discovered and defined several NK cell receptors and the pathway of NK cell differentiation from stem cell. These studies have impacted clinical bone marrow transplantation and immunotherapy of tumors.

Genomic Dosage Disorders: Diagnostic Insights and Challenges

Nancy Spinner, PhD
Professor
Genetics in Pediatrics
University of Pennsylvania School of Medicine

Wednesday, April 8, 2009 - 4:30 PM
Health Science Center, K-069

Faculty Sponsor: Christine Disteche, Ph.D.

Why Attend?
Cytogenetics is experiencing a Renaissance, lead by the introduction of array based technology. We've been using high density SNP arrays in the both our clinical Cytogenetics (now CytoGenomics) and research laboratories. The combination of genotyping and intensity data in this platform has revealed a new view of the genome in patients with congenital abnormalities. We've identified new mechanisms of disease, shed light on meiotic and mitotic origins of several types of abnormalities, and diagnosed single gene disorders (dominant and recessive), which contribute to the construction of a gene dosage map. Dr. Spinner received her BS from Brandeis University, PhD in Genetics from UC Berkeley and Fellowship training in Genetics and Cytogenetics at The University of Pennsylvania. She is currently on the Faculty at Penn, in the Departments of Pediatrics and Genetics and she is the Director of the Clinical CytoGenomics Laboratory at The Children's Hospital of Philadelphia.

Gene Networks as Sensors and Drivers of Disease

Eric Schadt, PhD
Executive Scientific Director
Genetics
Rosetta Inpharmatics LLC

Wednesday, April 1, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Ray Monnat, M.D.

Why Attend?
Molecular biology has been remarkably successful at revealing mechanisms and interactions between DNA, RNA, and protein biosynthesis, and is beginning to reveal the inner workings of cells. The genomics revolution has extended this approach by providing new tools to take comprehensive 'snapshots' of the molecular states of cells. These data-rich snapshots have allowed us, in turn, to begin to build whole gene networks that define physiological states, and that link and predict how changes in molecular states alter physiology. Dr. Schadt's talk will describe how whole gene networks are constructed, and how they are being used to gain new insights into the origin of human disease, especially the common diseases that are important causes of premature disability and death.

Dr. Schadt received his B.S. in Applied Mathematics/Computer Science from California Polytechnic State University, his M.A. in Pure Mathematics from UCD, and his Ph.D. in Bio-mathematics from UCLA (requiring Ph.D. candidacy in molecular biology and mathematics). He joined Rosetta in 1999, and formed the Genetics/Systems Biology department at Merck when Rosetta was acquired by Merck in 2001. Dr. Schadt is also a UW Affiliate Associate Professor of Biostatistics, and was recently elected a Fellow to the Institute of Systems and Synthetic Biology at Imperial College, London.

Genetic and Epigenetic Regulation of Gene Expression in Normal Development and Diseases of Skeletal Muscle

Stephen Tapscott
Member
Divisions of Human Biology and Clinical Research
Fred Hutchinson Cancer Research Center

Wednesday, March 11, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Ray Monnat, M.D.

Why Attend?
Skeletal myogenesis is a model system for defining the molecular mechanisms of regulating a complex program of gene expression in a dynamic system. MyoD is a central factor in this program and has been used to elucidate general rules for how complex cellular programs might evolve and achieve predictable complex behaviors. Dr. Tapscott will discuss his work on the regulation of gene expression in normal myogenesis and in rhabdomyosarcomas.

Dr. Tapscott earned his BA at Hampshire College and MD/PhD from the University of Pennsylvania, where he also completed medical inter,ship and neurology residency. He completed postdoctoral training in molecular biology at the Fred Hutchinson Cancer Research Center and has been a faculty member there since 1991.

Chromatin and G-quadruplex Functions at Telomeres and Beyond

Brad Johnson, MD, PhD
Assistant Professor
Pathology/Lab Medicine
University of Pennsylvania

Wednesday, March 4, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Ray Monnat, M.D.

Why Attend?
Telomeres are the physical and functional 'caps' on the ends of chromosomes. Telomere defects are now known to contribute to several degenerative diseases as well as cancer. Dr. Johnson's talk will describe how telomeres are maintained by a combination of chromatin and helicase-dependent recombination pathways. He will also present new evidence for the role of G-quadruplex structures formed by G-rich telomeric DNA in telomere capping and the regulation of transcription.

Dr. Johnson received his BS from Yale, and MD and PhD from Stanford. He did residency training in Clinical Pathology at Brigham and Women's Hospital, and postdoctoral research at MIT before joining the faculty at Penn. Dr. Johnson is currently Assistant Professor of Pathology and Assistant Director of the Clinical Immunology Laboratory at the Hospital of the University of Pennsylvania.

Lost in Translation: Ribosomes in Hematopoiesis

Akiko Shimamura, MD, PhD
Associate Member
Division of Pediatric Hematology/Oncology
Fred Hutchinson Cancer Research Center

Wednesday, February 25, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Ray Monnat, M.D.

Why Attend?
Ribosomes have long been considered "housekeeping" organelles whose chief-or sole-function is to translate the information contained in mRNAs into cellular proteins. A surprising recent twist in this story was the identification of ribosomal gene mutations in a group of hematologic disorders characterized by marrow failure and leukemia predisposition. Dr. Shimamura will review the emerging field of ribosomal diseases, and discuss models for disease that arise from ribosomal abnormalities or dysfunction.

Dr. Shimamura received her B.A. from Princeton University and did her M.D. and Ph.D. training at the University of Rochester. She joined the faculty at Harvard after Internship and Residency training at Johns Hopkins, and a Fellowship at the Dana-Farber and Children's Hospital in Boston. She was recruited to the UW in 2007, and is an Associate Member at the Fred Hutchinson in 2008. She directs a research lab at the FHCRC, and is head of the Marrow Failure Clinic at Seattle Children's Hospital.

Translating Pathways to Pancreatic Cancer

Sunil Hingorani, MD, PhD
Assistant Member
Clinical Research and Public Health Sciences Division
Fred Hutchinson Cancer Research Center

Wednesday, February 18, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Ray Monnat, M.D.

Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the U.S. Recent genomic analyses of this common killer have revealed core signaling pathways that are altered in nearly all pancreatic cancers, and thus are new targets for pancreatic cancer diagnosis and therapy. Dr. Hingorani will discuss these findings, and how mouse models can be used to explore the clinical translation of these exciting new results.

Dr. Hingorani received his B.A., M.D. and Ph.D. from Yale. He did internship, residency and fellowship training in Boston at the Brigham & Women's Hospital, Dana-Farber and M.I.T. before joining the faculty at Penn. He was recruited to the Fred Hutchinson and UW in 2005, where he has a research lab and directs the Pancreatic Cancer Specialty Clinic at the Seattle Cancer Care Alliance.

Patient-Specific Models of Glioma Growth and Invasion: Predictive Capability and Clinical Utility

Kristin Swanson, PhD
Research Associate Professor, UW Medicine Pathology
Adjunct Associate Research Professor, Applied Mathematics
University of Washington

Wednesday, February 11, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Monnat

Archaeoctyes: Monocytes as Universal Probes for Disease

Stephen Schwartz, MD, PhD
Professor
Pathology
University of Washington

Wednesday, February 4, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Monnat

Roles of Transcription in Genomic Stability or Instability

Philip Hanawalt, PhD
Professor
Biological Sciences
Stanford University

Wednesday, January 28, 2009 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Loeb

Studying Hematopoietic Disease with Genetics & Genomics

Yajuan Liu, PhD
Senior Fellow
Medical Genetics
University of Washington

Wednesday, January 21, 2009 - 4:30 PM
Health Science Bldg, K-069

Faculty Sponsor: Dr. Monnat

"Mitotic Reduction Divisions (Somatic Meiosis) in polyploid Hepatocytes"

Markus Grompe, MD
Professor
Molecular & Medical Genetics and Pediatrics
Oregon Health & Science University

Wednesday, December 10, 2008 - 4:30 PM
Health Science Center, K-069

Faculty Sponsor: Dr. Monnat

FEN1 Mutations Result in Autoimmunity, Chronic Inflammation and Cancers

Binghui Shen, PhD
Professor
Radiation Biology
City of Hope

Wednesday, December 3, 2008 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Loeb

“Quantum Dots for Cancer Imaging and Therapeutics�

Xiaohu Gao, PhD
Assistant Professor
Bioengineering
University of Washington

Wednesday, November 19, 2008 - 4:30 PM
Health Science Center, K-069

Faculty Sponsor: Dr. Monnat

Neuroregeneration in the Cerebral Cortex: Impossible and Crazy?

Robert Hevner, M.D., Ph.D.
Professor
Neurological Surgery, Seattle Children's Hospital; and UW Medicine Pathology
University of Washington

Wednesday, November 12, 2008 - 4:30 PM
Health Science Center, K-069

Faculty Sponsor: Dr. Monnat

"Pathogenesis of NASH: new insights from mice with metabolic syndrome"

Geoffrey Farrell, MD
Director/Professor
Gastroenterology and Hepatology
Australian National University

Wednesday, November 5, 2008 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Matthew Yeh

"The Instability of Genetic Instability: Pathways Suppressing Mutator Phenotypes in Yeast"

Alan Herr, PhD
Senior Fellow
Pathology
University of Washington

Wednesday, October 29, 2008 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Brad Preston

"Control of Cardiovascular Signaling by RGS Proteins"

William Mahoney, PhD
Senior Fellow
Pathology
University of Washington

Wednesday, October 22, 2008 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Monnat

Exploring the Interface Between Glial Progenitors and Gliomas

Peter Canoll, MD, PhD
Assistant Professor
Department of Clinical Pathology
Columbia University

Wednesday, October 15, 2008 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Tom Montine

Pancreatic Cancer: Emerging Ideas About How the Cancer Forms

Teri Brentnall, MD
Professor
Departments of Medicine and Pathology
University of Washington

Wednesday, October 1, 2008 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Rabinovitch

The Blood Brain Barrier in Parkinson's disease: Old Foe or New Friend

Dr. Paul Carvey
Dean
Rush Medical School

Wednesday, February 20, 2008 - 4:30 AM
Health Sciences Building, T639

Faculty Sponsor: Dr. Zhang

Roles of cytokines in regulation of bone mass

Brendan Boyce
Director of Surgical Pathology
Department of Pathology and Laboratory Medicine
University of Rochester Medical Center in New York

Wednesday, June 6, 2007 - 4:30 PM
HSC, K-069

Faculty Sponsor: Dr. Larry True

Membrane Electroporation for Cancer Therapies and Direct Gene Electrotherapy

Dr. Eberhard Neumann
Bielefeld, Germany
Department of Chemistry
University of Bielefeld

Wednesday, May 30, 2007 - 4:30 PM
HSC, K-069

Faculty Sponsor: Dr. Lawrence Loeb
International speaker from Germany

PathPresents: Molecular Diagnosis of Limb-Girdle and Congenital Muscular Dystrophies

Steven A. Moore, M.D., Ph.D.
Co-Director
Wellstone Muscular Dystrophy Research Center
University of Iowa

Wednesday, March 14, 2007 - 4:30 PM
HSC, K-069

Faculty Sponsor: Dr. Hevner
Sponsored by PathPresents.

Path Presents: The Isoprostanes and Related Compounds as Markers and Mediators of Oxidant Stress in Human Disease: New Insights and Current Controversies.

Jason D. Morrow
F. Tremaine Billings Professor of Medicine and Pharmacology
Chief, Division of Clinical Pharmacology
Vanderbilt University School of Medicine

Wednesday, February 7, 2007 - 4:30 PM
HSC, K-069

Faculty Sponsor: Dr. Thomas Montine

Proteomics-Based Strategies to Study Hepatitis C Virus-Related Hepatocellular Carcinoma

Laura Beretta
Associate Member, FHCRC, Affiliate Associate Professor, UW
Pathology
UW - Pathology

Wednesday, June 7, 2006 - 4:00 AM
HSB, K-069

“Global analysis of X chromosome dosage compensation"

Brian Oliver
Section Chief of Developmental Genomics
National Institutes of Health, Bethesda, MD

Wednesday, May 10, 2006 - 4:30 PM
HSB, K-069

Faculty Sponsor: Christine Disteche

**NOTE SPECIAL TIME 1:30PM** "Zebrafish as a model for Cancer, Pigmentation, and Systems Biology"

Keith Cheng
Jake Gittlen Cancer Research Foundation
Penn State College of Medicine

Wednesday, April 26, 2006 - 1:30 PM
HSB, K-069

Faculty Sponsor: Dr. Loeb

“Tough mice and aging: How to survive with a damaged proteome"

Steve Clarke
Professor
Department of Chemistry and Biochemistry
UCLA

Wednesday, May 4, 2005 - 4:30 PM
health science bldg, K-069

Faculty Sponsor: George Martin

Coenzyme Q and Aging: Dr. Jekyll or Mr. Hyde?

Catherine Clarke
Professor
Dept Chemistry and Biochemistry
UCLA

Wednesday, April 27, 2005 - 4:30 PM
Health Science Bldg, K-069

Faculty Sponsor: Tony Parks

"The liver as a model system for cell growth, proliferation, and carcinogenesis"

Jeffrey Albrecht
Associate Professor
Medicine
University of Minnesota

Wednesday, March 9, 2005 - 4:30 PM
Health Science Bldg, K-069

Faculty Sponsor: Tony Parks

“Recombomice" Shed Light on Homologous Recombination in Mammals

Bevin Engelward, Sc.D.
Associate Professor of Molecular Toxicology
Biological Engineering Division
MIT

Wednesday, March 2, 2005 - 4:30 PM
Health Science Bldg, K-069

Faculty Sponsor: Ray Monnat

"DNA Repair: Winning the Race with Replication"

Dr. John Heddle
Professor Emeritus & Senior Scholar
Department of Biology
York University, Toronto, Canada

Wednesday, February 16, 2005 - 4:30 PM
Health Science Bldg, K-069

Faculty Sponsor: Dr. Loeb

Unrepaired G1 DNA breaks can transit S-phase for repair by homologous recombination

Dr Yannick Saintigny

Wednesday, January 12, 2005 - 4:30 PM
Health Sciences Center, T-747

Faculty Sponsor: Dr. Ray Monnat

"Genome Maintenance, Telomeres and RecQ Helicases"

Dr. Judith Campisi
Professor
Lawrence Berkeley Laboratory, Center on the Economics and Demography of Aging
University of California, Berkeley

Wednesday, January 5, 2005 - 3:00 PM
HSB, K-069

Faculty Sponsor: Dr. Rabinovitch

“Defective DNA Damage Responses and Neurodegeneration and Brain Tumors."

Peter McKinnon, Ph.D.
Dept of Genetics,St. Jude Children's Research Hospital, Memphis, TN
Pathology
University of Washington

Wednesday, December 8, 2004 - 4:30 PM
HSB, K-069

Faculty Sponsor: Ray Monnat

The collagen VI muscular dystrophies: new insights into their molecular pathology and genetic basis

Shireen Lamande
Departmenet of Pediatrics
University of Melbourne, Australia

Wednesday, November 17, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Peter Byers

The Molecular Architecture of Signal Transduction Complexes

John D. Scott
Scientist
Oregon Health Sciences University

Wednesday, October 20, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Stephen Schwartz

Imaging of Angiogenesis & Lymphangiogenesis in Mouse Models of Disease

Donald McDonald
Professor of Anatomy
University of California, San Francisco

Wednesday, October 6, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Stephen Schwartz

Evolving Concepts in Soft Tissue Neoplasia

Christopher Fletcher
Professor and Director of Surgical Pathology
Brigham & Women's Hospital
Boston, MA

Wednesday, September 22, 2004 - 4:30 PM
Health Sciences Center, Room T-733

Faculty Sponsor: Dr. Brian Rubin

Seminar Title: TBA

Paul DiCorleto
Director
Lerner Institute
Cleveland Clinic

Wednesday, July 14, 2004 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Dan Bowen-Pope

Cardiomyopathy of Dystrophy: Primary Mechanisms and Experimental Therapeutics

Joseph Metzger
Professor
Departments of Physiology and Internal Medicine
University of Michigan

Tuesday, July 13, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Regulation of Cell Growth and Cell Size by the TSC-mTOR Pathway

Kun-Liang Guan
Professor
Department of Biological Chemistry
University of Michigan

Monday, July 12, 2004 - 4:30 PM
Health Sciences Center, K-069

Progression vs Regression of Chronic Kidney Disease: Fact or Fantasy

Agnos Fogo
Professor
Department of Pathology
Vanderbilt University

Thursday, June 17, 2004 - 10:30 AM
Health Sciences Center, Room T-747

Faculty Sponsor: Dr. Charles Alpers

Perlecan Heparan Sulfate in the Control of Vascular Smooth Muscle Cell Proliferation During Development and Disease

Mary Wiser-Evans
Assistant Professor
Departments of Pediatrics and Cell and Developmental Biology
University of Colorado

Tuesday, June 8, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Michael Reidy

Pleiotropic Effects of HDL and Lysophospholipids in the Vasculature and Heart

Bodo Levkau
Professor
Institute of Pathophysiology
University of Essen

Monday, June 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Elaine Raines

Genetics on Embryonic Stem Cells; A Shortcut for Functional Genomics

Andras Nagy
Professor
Department of Molecular and Medical Genetics
University of Toronto

Wednesday, May 26, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Dr. Stephen Schwartz

Barking Up the Right Vascular Tree with Sphingosine 1-Phosphate

Timothy Hla
Professor of Cell Biology and of Genetics and Developmental Biology
Director, Center for Vascular Biology
University of Connecticut School of Medicine

Thursday, May 20, 2004 - 4:30 PM
Health Sciences Center, Room T-747

Faculty Sponsor: Dr. Michael Reidy

Histone Methyltransferases in Tumor Suppression

Shi Huang
Associate Professor
The Burnham Institute
La Jolla, California

Wednesday, May 19, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Dr. Marshall Horwitz

New Entities in Pediatric Renal Neoplasia

Pedram Argani
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine

Wednesday, May 12, 2004 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Brian Rubin

Identification of Therapeutic Targets in Clinical Practice: Lessons Learned from the HER2 Story

Stuart Schnitt
Professor
Department of Pathology
Harvard Medical School

Wednesday, May 5, 2004 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Brian Rubin

Genetic Basis of Aortic Aneurysms and Dissections

Dianna Milewicz
Professor
Department of Medical Genetics
University of Texas Medical School

Wednesday, April 28, 2004 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Eileen Mulvihill

Biological Roles of ADAMTS Metalloproteases

Suneel Apte
Associate Professor
Department of Molecular Medicine
CANCELED

Wednesday, April 21, 2004 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Ulrike Schwarze

The Fragile X Gene: Distinct Molecular and Neuropathologic Mechanisms Give Rise to Two Separate Syndromes

Paul Hagerman
Professor
Department of Biological Chemistry
University of California, Davis

Monday, March 15, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Brad Preston and Charles Laird

Development Gone Awry: Genetics and Pathology of Medulloblastoma

Charles Eberhart
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine

Wednesday, March 10, 2004 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Tom Montine

Vascular Calcification in Chronic Kidney Disease

William G. Goodman
Professor
Department of Medicine
U.C.L.A. School of Medicine

Wednesday, March 3, 2004 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Cecilia Giachelli

Utilizing Human Genetics to Understand Vascular Development

Dean Li
Associate Professor
Department of Medicine
University of Utah

Wednesday, February 25, 2004 - 4:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Dr. Stephen Schwartz

Characterization of Cancer-Associated Mutants of DNA Polymerase Beta

Joann Sweasy
Associate Professor
Departments of Therapeutic Radiology and Genetics
Yale University School of Medicine

Wednesday, February 11, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Dr. Larry Loeb

Mechanism of Lung Adenocarcinoma Induction by Jaagsiekte Sheep Retrovirus and Parallels with Human Lung Cancer

Dusty Miller
Member, FHCRC
Affiliate Professor, Department of Pathology
University of Washington

Wednesday, January 28, 2004 - 4:30 PM
Health Sciences Center, Room K-069

Faculty Sponsor: Dr. Tony Parks

Fundamental Issues in Engineered Vessel Development

Laura Niklason
Assistant Professor
Departments of Biomedical Engineering, Anesthesia and Surgery
Duke University

Friday, January 16, 2004 - 3:30 PM
Health Sciences Center, K-069

Faculty Sponsor: Chuck Murry and Thomas Wight

Prelamin A Processing and Progeria

Stephen Young, M.D.
Senior Investigator
Gladstone Institute of Cardiovascular Disease
University of California, San Francisco

Wednesday, December 17, 2003 - 4:30 PM
Health Sciences Center, K-069

Translational Control in Macrophage Inflammation

Paul L. Fox
Professor of Molecular Medicine
Department of Cell Biology
The Lerner Research Institute, Cleveland Clinic Foundation

Wednesday, December 3, 2003 - 4:30 PM
Health Sciences Center, K-069

Involvement of IKK Alpha in Rank-Mediated Osteoclastogenesis

Michelle Chaisson
Post-Doctoral Fellow
Amgen, Inc.

Wednesday, November 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069

A Murine Model of Intestinal Pseudo-Obstruction

Raj Kapur, M.D., Ph.D.
Associate Professor
Department of Pathology and Department of Laboratories
University of Washington and Children's Hospital and Regional Medical Center

Wednesday, November 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069

Many Genes and Many Tumors: Genetics of Uterine Leiomyomata

Cynthia Morton
Professor
Department of Pathology
Brigham and Women's Hospital, Boston, MA

Wednesday, October 8, 2003 - 4:30 PM
Health Sciences Center, Room K-069

Microscale Systems and Applications for Life-on-a-Chip

Deirdre Meldrum
Professor
Department of Electrical Engineering
University of Washington

Wednesday, June 11, 2003 - 4:30 PM
Health Sciences Center, Room K-069

Biotechnology Drug Discovery in the Post-Human Genome Era

Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories

Thursday, June 5, 2003 - 4:30 PM
Health Sciences Center, T-747

Genetic Chemoprotection of Hematopoietic Stem Cells: Implications for the Treatment of Genetic and Malignant Diseases

Hans-Peter Kiem
Associate Member
Fred Hutchinson Cancer Research Center

Wednesday, May 21, 2003 - 4:30 PM
Health Sciences Center, K-069

Cellular Adaptation to Client Protein Load on the Endoplasmic Reticulum

David Ron, M.D.
Professor
Departments of Medicine and Cell Biology
NYU School of Medicine

Wednesday, May 14, 2003 - 4:30 PM
Health Sciences Center, Room K-069

Yeast and Mouse Models for Exploring Telomere Function in Werner Syndrome

Brad Johnson, M.D., Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
University of Pennsylvania

Wednesday, May 7, 2003 - 4:30 PM
Health Sciences Center, Room K-069

Bacteriophages: Nature’s Self-replicating, Self-limiting Antibiotics

Betty Kutter, Ph.D.
Faculty Member
Department of Biophysics
Evergreen State College

Wednesday, April 30, 2003 - 4:30 PM
HSC, Room K-069

Why Is the Gastric Cardia Such a Big Deal When It Is So Small?

Henry Appelman, M.D.
Professor
Pathology
University of Michigan

Wednesday, April 23, 2003 - 4:30 PM
HSC, Room K-069

Discoidin Domain Receptors (DDRS) - Novel Collagen Receptors in the Vascular System

Michelle Bendeck, Ph.D.
Associate Professor
Laboratory Medicine and Pathobiology
University of Toronto

Wednesday, April 16, 2003 - 4:30 PM
HSC, Room K-069

Sex Chromosome Evolution: A Tale of the Smart, Sexy X Chromosome and the Degenerate Y

Jenny Graves
Professor
Comparative Genomics
Australian National University

Wednesday, April 2, 2003 - 4:30 PM
HSC, Room K-069

The Genetics and Biology of Tumor Suppression by p27/Kipl

Chris Kemp, Ph.D.
Affiliate Associate Professor
Department of Pathology
Fred Hutchinson Cancer Research Center

Wednesday, March 26, 2003 - 4:30 PM
HSC, K-069

Array CGH for High Resolution Analysis of Genomic Aberrations

Dan Pinkel, Ph.D.
Professor
Department of Laboratory Medicine
UCSF

Tuesday, February 25, 2003 - 4:30 PM
Health Sciences Center, Room K-069

Innate Immune Recognition and Response to Microbial Pathogens

Kelly Smith, Ph.D., M.D.
Department of Pathology
University of Washington

Wednesday, February 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069

The Role of Proteolysis in the Pathogenesis of Atherosclerosis

Peter Gough
Research Assistant Professor
Department of Pathology
University of Washington

Wednesday, February 12, 2003 - 4:30 PM
Health Sciences Center, Room K-069

Cellular and Molecualr Mechanisms of Diabetes-accelerated Atherosclerosis

Karin Bornfeldt, Ph.D.
Associate Professor
Department of Pathology
University of Washington

Wednesday, February 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069

Protein Interactions

Stan Fields, Ph.D.
Professor
Departments of Genome Sciences and Medicine
University of Washington

Tuesday, January 21, 2003 - 4:30 PM
Health Sciences Center, T-747

From Gene Expression Patterns to Antibody Diagnostics: A Pharmacogenomics Approach to Cancer Classification and Treatment

Douglas Ross, M.D., Ph.D.
Chief Scientific Officer
Applied Genomics Inc.

Wednesday, December 18, 2002 - 4:30 PM
HSC, K-069

Development of a Gene Expression Array-Based Diagnostic Tool for Lymphoma

Daniel E. Sabath
Associate Professor
Laboratory Medicine
University of Washington

Wednesday, December 4, 2002 - 4:30 PM
HSC, K-069

"Microarray Analysis in Cancer Research: Progress and Promise"

Paul Meltzer, M.D., Ph.D.
Senior Investigator
Cancer Genetics Branch
NIH, National Human Genome Research Institute

Wednesday, November 20, 2002 - 4:30 PM
Health Sciences Center, K-069

Molecular Pathology of the Vascular Form of Ehlers-Danlos Syndrome

Ulrike Schwarze, M.D.
Assistant Professor
Department of Pathology
University of Washington

Wednesday, November 13, 2002 - 4:30 PM
Health Sciences Center, K-069

Single Cell Proteomics

Norm Dovichi
Professor
Department of Chemistry
University of Washington

Wednesday, November 6, 2002 - 4:30 PM
HSC, K-069

DNA Repair Genes Select Stem Cells in Vivo

Stan Gerson, M.D.
Professor and Chief
Hematology/Oncology
Case Western Reserve University

Wednesday, October 30, 2002 - 4:30 PM
HSC, K-069

Multimodality Phenotyping: A Systematic Approach to Understanding Pathogenetic Mechanisms in Cardiovascular Disease

James Scott
Professor
Genetics and Genomics Research Institute
Imperial College of Science

Wednesday, October 16, 2002 - 4:30 PM
Health Sciences Center, K-069

Mouse Models Unravel the p53 Pathway

Gigi Lozano, Ph.D.
Professor and Geneticist
Department of Molecular Genetics
MD Anderson Cancer Center
University of Texas

Wednesday, October 2, 2002 - 4:30 PM
Health Sciences Center, K-069

Cell Growth Survival and Papillogenesis in Ovarian Epithelial Cancer

Santo Nicosia, M.D.
Professor
Interdisciplinary Oncology Program
Moffitt Cancer Center and Research Institute
University of South Florida

Wednesday, July 31, 2002 - 4:30 PM
Health Sciences Center, Room T-747

"Regulation of ErbB Ligand Signaling Networks in Cancer and Diabetes - Role of Ligand Trafficking and Processing"

Peter J. Dempsey, Ph.D.
Principal Scientist
Pacific Northwest Research Institute
Seattle, Washington

Wednesday, June 26, 2002 - 4:30 PM
Health Sciences Center, K-069

"Neurogenesis and Laminar Fate in the Developing Mouse Cerebral Cortex"

Robert Hevner, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington

Wednesday, June 5, 2002 - 4:30 PM
Health Sciences Building, K-069

"Immunohistochemistry in Urologic Tumor Pathology"

Mark Wick, M.D.
Associate Director
Surgical Pathology
University of Virgina Health System

Wednesday, May 29, 2002 - 4:30 PM
Health Sciences Building, K-069

Membranoproliferative/Cryoglobulinemic (Hepatitis C Associcated) Glomerulonephritis: A Disease of Mice and Men

Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington

Wednesday, May 15, 2002 - 4:30 PM
Health Sciences Center,