Cardiovascular Research Center Breakfast Club 

The Cardiovascular Research Center Breakfast Club meets on Tuesday mornings under the sponsorship of the Reaction to Injury Program Project Grant and training grants in Cardiovascular Pathology and Cardiology.

Administrative support is provided by Steve Schwartz's office. If you have any questions please contact JP Paredes at jparedes@u.washington.edu or 897-1539.

No upcoming seminars are currently posted.


Recent Breakfast Club Lectures

The one-dimensional and three-dimensional architecture of the genome

William Stafford Noble, PhD
Professor
Dept. of Genome Sciences; Dept. of Computer Science and Engineering
UW

Tuesday, October 4, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Zhi-jun Duan (Hematology; ISCRM)

Proteolytic Pathways in Immunity, MMPs as Effectors of Inflammation

William C. Parks, PhD
Professor, Division of Pulmonary and Critical Care Medicine, UW
Director, Center for Lung Biology, UW
Affiliate Investigator, Benaroya Research Institute

Tuesday, September 27, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Kelly Smith

Mechanisms for Cardioprotection and Regeneration

Loren J. Field, PhD
Professor
Medicine & Pediatrics
Indiana University School of Medicine.

Monday, September 19, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Charles E. Murry
Distingushed Lecture series

Platelet Hyperactivity and Inflammation: STAT3 Signaling in Platelets

Jing-Fei Dong, MD, PhD
Full Member, Puget Sound Blood Center Research Institute
Professor of Medicine, Division of Hematology
UW

Tuesday, September 13, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: William C. Parks

Local Controls of L-type Calcium Channels in Muscle

Luis Fernando Santana, Ph.D.
Professor
Physiology and Biophysics
UW

Tuesday, September 6, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Ca2+ Mediated Myocyte Hypertrophy, Death, and Regeneration

Steven R. Houser, Ph.D., FAHA
Laura H. Carnell Professor of Physiology and Medicine; Director, Cardiovascular Research Group
Chair, Department of Physiology
Temple University School of Medicine, Philadelphia

Tuesday, June 21, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Rong Tian

Mitochondria beyond ATP production

Georgios Karamanlidis, Ph.D.
Postdoctoral Fellow
Mitochondria and Metabolism Center
University of Washington

Tuesday, June 14, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Rong Tian

Supercharging Stem Cell-mediated Regeneration

Mark Sussman, Ph.D.
Professor, SDSU Heart Institute
Department of Biology
California State University, San Diego, California

Tuesday, June 7, 2011 - 9:00 AM
SLU 815 Mercer Street, Brotman Auditorium

Faculty Sponsor: Rong Tian

Insights into regulation of endothelial and smooth muscle function in vivo

William C. Sessa, Ph.D.
Professor of Pharmacology; Vice Chairman, Pharmacology; Director, Vascular Biology & Therapeutics Program
Yale University

Tuesday, May 31, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Stephen M. Schwartz

The Nitric Oxide/cGMP Pathway and Its Effects on Vascular Inflammation and Atherosclerosis

Andrew Cheng, M.D.
Fellow
Medicine/Cardiology
UW

Tuesday, May 24, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Francis Kim

Extracellular Matrix and the Control of Inflammation

Thomas N. Wight, Ph.D.
Director, Hope Heart Matrix Program, Benaroya research Institute
Professor of Pathology (Affiliate)
University of Washington

Tuesday, May 17, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Stephen M. Schwartz

Regulation of Cardiac Tissue Structure and Function by Nano-architectured Matrix Control

Deok-Ho Kim, Ph.D.
Assistant Professor
Bioengineering; Center for Cardiovascular Biology; Institute of Stem Cell and Regenerative Medicine
UW

Tuesday, May 10, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Chuck Murry

Vascular Biology and Health Disparities: Defining Molecular Pathways

Gary H. Gibbons, M.D.
Director, Cardiovascular Research Institute
Chairman, Department of Physiology; Professor of Medicine
Morehouse School of Medicine

Friday, May 6, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Stephen M. Schwartz
This is a Special Breakfast Club webcast from Atlanta

Regulation of TRPV1 by Phosphoinositides

Sharona E. Gordon, Ph.D.
Associate Professor
Physiology and Biophysics
UW

Tuesday, May 3, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Eric Senning

Preventing Vein Graft Stenosis in Peripheral Vascular Surgery

Katie Moreno, M.D.
General Surgery Resident
Surgery, VA Puget Sound health Care System
University of Washington

Tuesday, April 26, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Michael Sobel

Multi-Scale Modeling of the Heart: From Crossbridge to Organ

Andrew McCulloch, PhD
Professor
Bioengineering and Medicine
University of California, San Diego

Tuesday, April 19, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Michael Regnier
Distinguished Lecture Series

Decoding cell lineage from acquired mutations using deep sequencing

Marshall Horwitz, MD, PhD
Professor
Pathology; Institute for Stem Cell & Regenerative Medicine
UW

Tuesday, April 5, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Mark Majesky

Slicing tissue with photons: non-invasive 3D imaging of microstructure andmicrocirculation in tissue in vivo

Ruikang K. Wang, PhD
Professor
Bioengineering
UW

Tuesday, March 29, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: Michael Regnier, Bioengineering

Thin-Filament Related Cardiomyopathies: An Integrative Approach to a Complex Disorder

Jill Tardiff, MD, PhD
Associate Professor of Physiology and Biophysics
Associate Professor of Internal Medicine (Adult Cardiology)
Albert Einstein College of Medicine, Bronx, New York

Tuesday, March 22, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: Michael Regnier, Bioengineering,
DISTINGUISHED LECTURE Series

The Sequelae of Dysfunctional BMPRII Signaling

Marlene Rabinovitch, MD
Pfizer Visiting Professorship in Pulmonary Vascular Disease
Dwight and Vera Dunlevie Professor of Pediatric Cardiology
Stanford University School of Medicine

Tuesday, March 15, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: William C. Parks

Role of transcription factor CHF1/Hey2 in cardiac differentiation and hypertrophy

Farid Moussavi-Harami, M.D.
Cardiology Fellow
Department of Internal Medicine
UW

Tuesday, March 8, 2011 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Michael Chin

Unraveling Genome Architecture

Zhi-jun Duan, Ph.D.
Research Assistant Professor
Department of Hematology
UW Institute for Stem Cell and Regenerative Medicine

Tuesday, March 1, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: Steve Schwartz, Pathology

University of North Carolina at Chapel Hill

James E. Faber, Ph.D
Professor, Department of Cell and Molecular Physiology
McAllister Heart Institute
University of North Carolina at Chapel Hill

Tuesday, February 22, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: Steve Schwartz, Pathology
This is a podcast from Chapel Hill. Dr. Faber is not physically present at the UW SLU campus but is webcasting from UNC, Chapel Hill.

Insulin Resistance and Cardiovascular Dysfunction – Elucidating Novel Mechanisms

E. Dale Abel, M.D., D Phil
Professor of Medicine and Biochemistry
Chief, Division of Endocrinology, Metabolism and Diabetes
University of Utah School of Medicine

Tuesday, February 15, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: Rong Tian, UW Mitochondria and Metabolism Center
DISTINGUISHED LECTURE Series: Dr. Abel is a world expert in the regulation of myocardial biology and metabolism by insulin signaling. His work in the last decade has significantly advanced our knowledge of disease mechanisms for the cardiomyopathy caused by metabolic disorders. Representative publications: 1. Cardiac remodelingin obesity. Physiol Rev. 2008 Apr;88(2):389-419 2. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab. 2007 Oct;6(4):294-306

Targeting chromatin to accelerate tumor cell senescence

Stephen Kron, MD, PhD
Ludwig Center for Metastasis Research
The University of Chicago

Tuesday, February 8, 2011 - 9:00 AM
SLU, 815 Mercer Street, Brotman Auditorium

Faculty Sponsor: Charles E. Murry, Pathology and Bioengineering

Gene Regulation Beyond Promoters: Direct, Complete, Integrated, Transcriptional Analysis

Daniel Morris, Ph.D.
Research Assistant Professor
Department of Anesthesiology
UW

Tuesday, February 1, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: Debra Schwinn, Anesthesiology and Pain Medicine

Novel regulators of ischemic injury and ventricular remodeling

Thomas Force, MD
James C. Wilson Professor of Medicine
Clinical Director, Center for Translational Medicine
Thomas Jefferson University

Tuesday, January 25, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: Rong Tian, Mitochondria and Metabolism Center
DISTINGUISHED LECTURE Series: Dr. Force is a recognized leader in stress-induced signaling cascades in cardiac growth and survival. His lab has pioneered research on the cardiotoxicity caused by tyrosine kinase inhibitor cancer therapeutics. His recent work has elucidated the isoform-specific role of GSK-3 in cardiac hypertrophy. Representative publications: 1. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest. 2010 2. Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol Cell Biol. 2009 3. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 2006

The State of Seattle Biotech in 2011

Luke Timmerman
National Biotechnology Editor
Xconomy

Tuesday, January 18, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: David Dichek

Enhanced peer review of NIH grant proposals: how the process is supposed to work but often doesn't: A panel discussion with current members of NIH study sections and review groups

Michael E. Rosenfeld, PhD; Karin Bornfeldt, PhD; William Parks, PhD; Jay Heinecke, MD
Members of NIH Study Sections
Scool of Medicine
UW

Tuesday, January 11, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: Steve Schwartz
Michael E. Rosenfeld, PhD Professor, Environmental & Occupational Health Sciences; Professor, Pathology Karin Bornfeldt, PhD Professor, Pathology, Diabetes and Obesity Center of Excellence William Parks, PhD Professor, Center for Lung Biology Jay Heinecke, MD Professor, Division of Metabolism, Endocrinology and Nutrition

HDL, inflammation, and atherosclerosis. A paradigm shift?

Tomas Vaisar, PhD
Research Assistant Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
UW

Tuesday, January 4, 2011 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Adult Stem Cells for Cardiac Repair and Regeneration: In it to WNT

Ronglih Liao, PhD
Associate Professor of Medicine
Harvard Medical Schoopl

Tuesday, December 14, 2010 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: Rong Tian

Generation of S1P -based therapy for muscular dystrophy

Hannele Ruohola-Baker, PhD
Professor
Biochemistry
UW

Tuesday, December 7, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Taming the Beast: Structural biology of alphaB-crystallin, a small heat shock protein implicated in cardiomyopathy

Rachel E, Klevit, D. Phil.
Professor
Biochemistry and Biomolecular Structure Center
UW

Tuesday, November 30, 2010 - 9:00 AM
SLU 815 Mercer Street, Brotman Auditorium

Microchimerism: For better or for worse?

J. Lee Nelson, M.D.
Member, Fred Hutchinson Cancer Research Ctr
Professor, Rheumatology, University of Washington
UW

Tuesday, November 23, 2010 - 9:00 AM
SLU, 815 Mercer Street, Admin Bldg. C, Orin Smith Auditorium

The role of phosphodiesterases in inflammation

Angie Hertz
Predoctoral Fellow
Pharmacology
UW

Tuesday, November 16, 2010 - 8:30 AM
SLU, 815 Mercer Street, Brotman Auditorium

Transcriptional regulatory circuits controlling mitochondrial function in the developing and diseased heart

Daniel P. Kelly, MD
Scientific Director
Burnham Institute for Medical Research, Orlando, FL

Tuesday, November 9, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

The Contribution of Mitochondrial Reactive Oxygen Species to Cellular Signaling

Brian J. Hawkins, PhD
Assistant Professor
Anesthesiology and Pain Medicine; Researcher, Mitochondria and Metabolism Center
UW

Tuesday, November 2, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Mitochondria Production of Reactive Oxygen Species and its Role in Ischemia Reperfusion Injury

Wang Wang, MD, PhD
Assistant Professor
Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center
UW

Tuesday, October 26, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Application of Causal Analysis to the Vessel Wall

Stephen M. Schwartz, MD, PhD
Professor
Pathology
UW

Tuesday, October 19, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Mouse genetics is a powerful approach to understand vascular remodeling

Slava Korshunov, PhD
Assistant Professor of Medicine
Aab Cardiovascular Research Institute
University of Rochester School of Medicine and Dentistry, Rochester, NY

Tuesday, October 12, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Mitochondrial Dynamics as Studied by Fourier Imaging Correlation Spectroscopy

Eric Senning, PhD
Sr. Fellow
Physiology & Biophysics
UW

Tuesday, October 5, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Coupled gating of L-type calcium channels

Edward P. Cheng
Predoctoral Fellow
Physiology and Biophysics
UW

Tuesday, September 28, 2010 - 9:00 AM
SLU 815 Mercer Street, Admin Bldg C, Orin Smith Auditorium

Metabolic Remodeling and Dysregulation of Lipid Dynamics in Diseased Hearts

E. Douglas Lewandowski, PhD
Professor, Physiology & Biophysics, and Medicine
Director, Program in Integrative Cardiac Metabolism
University of Illinois at Chicago

Tuesday, July 13, 2010 - 8:30 AM
SLU, 815 Mercer Street, Brotman Auditorium

Faculty Sponsor: Rong Tian
.

Mapping gene expression subsets in systemic sclerosis to molecular pathways and concordant mouse models

Michael L. Whitfield, PhD
Assistant Professor
Genetics
Dartmouth Medical School

Tuesday, June 22, 2010 - 8:30 AM
SLU, 815 Mercer St, Brotman Auditorium

Faculty Sponsor: Stephen M. Schwartz, MD, PhD

Aortic Dissections, Vascular Diseases and ACTA2 Mutations

Dianna M. Milewicz, MD, PhD
Professor and Director
Medical Genetics
University of Texas Medical School at Houston

Tuesday, June 1, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg. C, Orin Smith Auditorium

Faculty Sponsor: Stephen M. Schwartz, MD, PhD
WEBINAR

Toggling among pluripotent states in embryonic stem cells

Carol Ware, PhD
Professor
Comparative Medicine
Institute for Stem Cell and Regenerative Medicine

Tuesday, May 25, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Quantifying Flow-induced Mechanical Stresses to Understand their Role in Vascular Disease

Alberto Aliseda, PhD
Assistant Professor
Mechanical Engineering
UW

Tuesday, May 18, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Mechanics and Mechanical Factors in the Structure-Function Relations of Endothelials and Platelets

Nathan J. Sniadecki, PhD
Assistant Professor
Mechanical Engineering
UW

Tuesday, May 11, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Mechanistic studies of myofilament protein phosphorylation modulating striated muscle contraction

Vijay S. Rao, PhD
Senior Fellow
Heart and Muscle Mechanics Laboratory, Bioengineering
UW

Tuesday, May 4, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Magnetic resonance imaging - a non-invasive method to study atherosclerosis progression and risk assessment

Chun Yuan, PhD
Professor of Radiology
Vascular Imaging Lab
UW

Tuesday, April 27, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Vascular gene therapy: a vector and a transgene that work!

David A. Dichek, MD
Professor of Medicine, Adjunct Professor of Pathology, John L. Locke, Jr. Family Endowed Chair in Medicine Associate Director for Research
Medicine/Cardiology
UW

Tuesday, April 20, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

S100A9 Has Disparate Affects in Neutrophils and Dendritic Cells, but Myeloid S100A9-Deficiency Does Not Affect Atherosclerosis and Insulin Resistance

Michelle Averill, PhD
Senior Fellow, Karin Bornfeldt Lab
Pathology
UW

Tuesday, April 13, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Engineering Vascularized Human Cardiac Tissue for Heart Repair

Kareen L. Kreutziger, PhD
Postdoctoral Fellow
Pathology
UW

Tuesday, April 6, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Using simulation methods to address biomedical problems

Valerie Daggett, PhD
Professor
Bioengineering
UW

Tuesday, March 30, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Machine learning approaches for understanding the genetic basis of complex traits

Su-In Lee, PhD
Assistant Professor
Computer Science & Engineering; and Genome Sciences
UW

Tuesday, March 9, 2010 - 8:30 AM
Health Sciences Building, K-069

Neuregulin Signaling and Subtype Specialization in Stem Cell Derived Cardiomyocytes

Michael Laflamme, MD, PhD
Assistant Professor
Pathology, Center for Cardiovascular Biology Institute for Stem Cell & Regenerative Medicine
UW

Tuesday, March 2, 2010 - 8:30 AM
Health Sciences Building , K-069

Use of the Mouse Conditional and Null Alleles of the Type III Sodium-Dependent Phosphate Cotransporter PiT-1

Maria Festing, PhD
Senior Fellow, Ceci Giachelli Lab
Bioengineering
UW

Tuesday, February 23, 2010 - 8:30 AM
Health Sciences Building , K-069

Regulation of Neointimal Hyperplasia by Sphingosine-1-Phosphate in Mice

Guenter Daum, PhD
Research Associate Professor
Surgery
UW

Tuesday, February 16, 2010 - 8:30 AM
Health Sciences Building , K-069

Biomechanics in carotid atherosclerosis and abdominal aortic aneurysms

Gador Canton, PhD
Senior Fellow
Radiology, Vascular Imaging Laboratory
UW

Tuesday, February 9, 2010 - 8:30 AM
Health Sciences Building , K-069

Using BAC Recombineering for the Analysis of Cardiac Progenitors

John L. Mignone, MD, PhD
Cardiology Fellow, Murry Lab
Pathology
UW

Tuesday, February 2, 2010 - 8:30 AM
Health Sciences Building , K-069

When Muscle Runs Out of Gas: nNOS Function in Skeletal and Cardiac Muscle

Justin Percival, PhD
Research Assistant Professor
Physiology and Biophysics
UW

Tuesday, January 26, 2010 - 8:30 AM
Health Sciences Building , K-069

Role of microRNA-155 in inflammatory/immune responses

John M. Harlan, MD
Professor of Medicine
Division of Hematology
UW

Tuesday, January 19, 2010 - 8:30 AM
Health Sciences Building , K-069

Proteolytic Pathways in Immunity

William C. Parks, Ph.D.
Professor of Medicine
Center for Lung Biology
UW

Tuesday, January 12, 2010 - 8:30 AM
Health Sciences Building , K-069

The State of Seattle’s Biotech Industry

Luke Timmerman
National Biotechnology Editor
Xconomy

Tuesday, January 5, 2010 - 8:30 AM
Health Sciences Building, K-069

Exome Sequencing & Human Disease

Jay Shendure, MD, PhD
Assistant Professor
Dept. of Genome Sciences
UW

Tuesday, December 15, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

The what, why, and where of perivascular cells

Morayma Reyes, MD, PhD
Assistant Professor
Pathology and Lab Medicine
UW

Tuesday, December 1, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Metabolic spectroscopy: New insights into mitochondrial adaptation to stress and disease

David Marcinek, PhD
Research Assistant Professor
Dept. of Radiology
UW

Tuesday, November 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
The ability of mitochondria to adapt to physiological stress is a key component of normal cell function. My talk will focus on new insights from in vivo metabolic spectroscopy in understanding the adaptive response of mitochondria and cell metabolism to oxidative and energetic stress. I will present results from multiple disease models illustrating how the coupling of oxidative phosphorylation, mitochondrial biogenesis, and glycolysis form an integrated system and how breakdown of this integration may underlie dysfunction in disease and aging.

Muscle Gene Regulation & Regulatory Cassettes for Gene Therapy

Stephen D. Hauschka, PhD
Professor
Dept. of Biochemistry
UIW

Tuesday, November 17, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Detailed analysis of the M-creatine kinase gene has provided many useful insights regarding the DNA control elements and transcription factors involved in the regulation of structural gene expression in skeletal and cardiac muscle. I will discuss recent studies based on quantitative proteomic strategies that have identified factors with no previously reported transcriptional function in striated muscle gene regulation, such as the Myc-associated zinc finger factor MAZ, and the Kruppel-like factor KLF3. Interestingly, MAZ expression increases >4-fold and KLF3 expression is initiated during skeletal muscle terminal differentiation – suggesting that both play functional roles during this transition. Many of the factors interact with control elements containing very similar conserved sequences that are not necessarily found in the transcription factor databases. Thus despite the presence of these sequence motifs in the regulatory regions of diverse muscle genes, these putative control elements have not previously been recognized as playing regulatory roles in muscle gene expression. For example, MAZ binds sequences such as CTCCTCCC and CTCCACCC that are quite divergent from the “database” binding site GGGAGGG, and control elements of the divergent sequence types have now been identified in the promoters of critical muscle regulatory genes such as: Myogenin, MEF2C, and Six4, as well as in more than a dozen structural genes such as: skeletal alpha-actin, desmin, and alpha-myosin heavy chain. Analogous studies with KLF3 have disclosed multiple KLF3 binding sites in the MCK promoter, and have identified two KLF3 isoforms within skeletal muscle nuclear extracts. Interestingly, the KLF3 protein does not appear to contain a transcriptional activation domain, thus in order to play a positive transcriptional role KLF3 must interact with one or more transcription factors that contain such domains. A search for KLF3 binding partners disclosed that it interacts with serum response factor (SRF), and a KLF3-SRF synergism can be demonstrated in COS cell transactivation studies. Interestingly, the KLF3-SRF synergism can occur with reporter gene constructs that contain KLF3 but no SRF DNA binding motifs. These studies suggest the novel regulatory concept that signal transduction pathways impinging on SRF can mediate the transcriptional control of genes lacking SRF binding sites via the interaction of SRF with KLF3, and association of the complex with KLF3 control elements such as C[A/C]CACCC. Since KLF3 motifs are present in many muscle genes and since SRF is expressed during early embryogenesis, the initiation of KLF3 expression during terminal differentiation could have important developmental consequences during myogenesis. If time permits, I will also discuss the design and evaluation of muscle-specific regulatory gene cassettes for the expression of therapeutic proteins in diseased striated muscles.

Exploring the extraordinary regenerative potential of the mammalian fetal heart

Timothy Cox, PhD
Research Associate Professor
Pediatrics, Division of Craniofacial Medicine
UW

Tuesday, November 10, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Skeletal muscle stem cells: from classic to eclectic

Zipora Yablonka-Reuveni, PhD
Professor
Dept. of Biological Structure
UW

Tuesday, October 27, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Background: Satellite cells are recognized as the main source of myogenic progeny in adult skeletal muscle. These cells are located underneath the myofiber basal lamina and are typically quiescent, but upon injury they can be rapidly recruited to provide myogenic progeny. It is yet unclear if satellite cells represent a uniform population of muscle stem cells, all of which are able to contribute differentiating progeny and self-renew, or if only some satellite cells possess self-renewal potential. It is also unclear if satellite cells are the sole source of myogenic progenitors in adult muscles. It has recently been shown that perivascular cells, grown ex-vivo, are able to contribute to adult myogenesis when delivered to host animal. This phenomenon may reflect a natural process occurring in vivo or may be initiated in culture, but is of potential importance to cell-based muscle therapy strategies. Our lab has been interested in defining the features of satellite and non-satellite cell myogenic sources in different muscle groups. Specifically, we focus on bona fide satellite cells and pericytes (contractile cells engulfing the endothelium in the microvasculature) from limb, diaphragm and extraocular muscles. Limb and diaphragm muscles are somite-derived and deteriorate in a range of muscular dystrophy diseases, whereas extrocular muscles derived from head mesenchyme and are not impacted in muscular dystrophy. Based on our recent data, we suggest the following hierarchy of proliferative performance and self-renewal capacity of myogenic stem cells: extraocular>diaphragm>limb. We are also interested in understanding the origin of pre-adipogenic progenitors in skeletal muscle and the balance between myogenic and adipogenic cell fates through the lifespan. Health relevance: Better understanding the regulation and distinctions of myogenic stem cells from different muscle groups, and the nature of cells contributing to intramuscular fibrosis and fat accumulation will provide important insights into therapies for combating muscle wasting disorders associated with aging (i.e., sarcopenia) and disease. Current support: National Institutes of Health (AG021566, AG013798, AG035377); Muscular Dystrophy Association (135908).

Platelet-Derived Growth Factor-C induces Fibrosis and Hepatocellular Carcinoma

Jean Campbell, PhD
Research Assistant Professor
Dept. of Pathology
UW

Tuesday, October 20, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Mechanisms of enhanced lung injury in febrile hyperthermia

Anne Lipke, MD
Senior Fellow
Division of Pulmonary and Critical Care Medicine
UW

Tuesday, October 13, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Lynn Schnapp, MD

CD40 and IFNα: Common Targets for Regulation of Autoimmune Disease and Atherosclerosis

Jeffrey A. Ledbetter, PhD
Research Professor
Division of Rheumatology
UW

Tuesday, October 6, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Jeffrey A. Ledbetter is a Research Professor of Rheumatology in the Dept. of Medicine at the University of Washington. He received his Ph.D. from the McArdle Laboratories for Cancer Research at the University of Wisconsin in 1978 and then did his postdoctoral training in Immunology at Stanford University with Dr. Leonard Herzenberg. Dr. Ledbetter spent much of his career in the biotech industry in Seattle, including 17 years with Bristol-Myers Squibb. He worked at Pacific Northwest Research Institute in Seattle for 5 years, then launched Trubion Pharmaceuticals in Seattle in 2001. Dr. Ledbetter joined the University of Washington in 2008 in the division of Rheumatology, Dept. of Medicine. Dr. Ledbetter has over 300 publications and is an inventor of over 40 issued patents. His most notable contributions include the discovery of CTLA4-Ig (Orencia), now approved by the FDA for therapy of patients with rheumatoid arthritis, and the first construction of chimeric anti-CD20 antibodies, now approved for therapy of B cell lymphoma and rheumatoid arthritis (Rituximab).

The role of cardiac metabolism in heart diseases

Rong Tian, MD, PhD
Professor and Director
Mitochondria and Metabolism Center
UW

Tuesday, September 29, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Disruption of the interaction between delta protein kinase C and the 'd' subunit of F1Fo ATPase: Implications for cardiac ischemia/reperfusion injury

Tiffany Nguyen
Graduate Student
Pharmacology and Toxicology Department
Medical College of Georgia, Augusta, GA

Tuesday, September 22, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Rong Tian, MD, PhD

Cell Signaling in Space and Time

John D. Scott, PhD
Edwin G. Krebs-Hilma Speights Professor
Dept. of Pharmacology
UW

Tuesday, September 15, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Can We Image a Plaque at Risk?

Mat J.A.P. Daemen, MD, PhD
Scientific Director of the Cardiovascular Research Institute Maastricht
Professor and Head of Pathology
University of Maastricht, The Netherlands

Tuesday, September 8, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Faculty Sponsor: Chun Yuan
Mat J. Daemen received his medical degree in 1983 at the University of Maastricht. After receiving his PhD in Pharmacology in 1987 and a post-doctoral fellowship at the dept of Pathology, University of Washington, Seattle, Wa, USA he started his residency in Pathology in 1989 and became a certified pathologist/ staff member at the dept. of Pathology at the University of Maastricht, professor of Pathology in 1997 and chairman of the department in 2001. He subsequently was vice dean (Research), director of the Clinical Laboratories and chairman of the Scientific Research Council in the Maastricht University Medical Center. In 2006 he was program director of the VIIth International Vascular Biology Meeting in the Netherlands and became Scientific Director of CARIM, the Cardiovascular Research Institute Maastricht (annual budget 23x106 €; 250 fte). He was one of the founding fathers of the Center for Translational Molecular Medicine (budget 400x106 €) and is a member of the scientific committee of the High Risk Plaque consortium, an international public private initiative (budget >30x106$) and co-founder of the small biotech company ACS Biomarker in 2007. He was (co)organiser of the Royal Netherlands Academy of Arts and Sciences Colloquium on “Plaque instability: from molecular regulation to diagnosis and therapy” held in Amsterdam from 27 to 29 Sept 2007. He is one of the co-founders of the Dutch Atherosclerosis Society and an expert in the molecular regulation of plaque (in)stability. He is program leader and member of the executive committee of the European Vascular Genomics Network, sponsored by the EU (FP6) and workpackage leader of the FP7 sponsored EU program Cardiorisk. He is co- spokesman of the recently established international graduate school EUCAR, a collaboration with the cardiovascular research Institute IMCAR in Aachen, He is coprincipal investigator of the CTMM project Circulating Cells and principal investigator of the CTMM project ParisK. He became President of the Dutch Society of Pathologists in 2009. His main research topic is the molecular regulation and imaging of atherosclerotic plaque (in)stability. He has published more than 180 scientific publications and supervised more than 30 PhD theses.

Targeted Proteomics Using Multiple Reaction Monitoring Mass Spectrometry

Daniel Martin, M.D.
Institute for Systems Biology

Tuesday, June 16, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Nitric Oxide and the Development of Insulin Resistance

Francis Kim, MD
Associate Professor of Medicine
Division of Cardiology
Harborview Medical Center

Tuesday, June 9, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Genes and Vascular Disease

Gail P. Jarvik, MD, PhD
Professor of Medicine and Head
Division of Medical Genetics
UW

Tuesday, June 2, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Critical Role of Intracellular Calcium in Mediating Insulin Secretion (But What Does It Actually Do?)

Ian R. Sweet, PhD
Research Assitant Professor
Division of Metabolism, Endocrinology and Nutrition
UW

Tuesday, May 26, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Sterol regulation of the macrophage immune response

Jay W. Heinecke, MD
Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
UW

Tuesday, May 19, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, SLU, 815 Mercer St., Admin Bld

Versican: A Matrix Molecule With Some Clout!

Thomas N. Wight, Ph.D.
Member and Director, Hope Heart Program
Benaroya Research Institute at Virginia Mason
Affiliate Professor, Pathology, UW

Tuesday, May 12, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Tumor Cell Metabolism: How is it different?

David M. Hockenbery, MD
Professor of Medicine, UWMC
Member, FHCRC

Tuesday, May 5, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Mapping Cell Fate through Somatic Mutations

Marshall Horwitz, MD, PhD
Professor of Pathology
Institute for Stem Cell and Regenerative Medicine
UW

Tuesday, April 28, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Shaping the vertebrate body: cell migration in development and disease

Douglas C. Weiser, PhD
Postdoctoral fellow
Department of Biochemistry
UW

Tuesday, April 21, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Matrix remodeling during lung injury and repair

Lynn M. Schnapp, MD
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
UW

Tuesday, April 14, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Translational control during monocyte/macrophage adherence

David Pritchard, PhD
Acting Instructor
Department of Pathology
UW

Tuesday, April 7, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Water, Energy and Life: Fresh Views from the Water’s Edge

Gerald H. Pollack, PhD
Professor
Department of Bioengineering
UW

Tuesday, March 31, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios?

David Wu, MD, PhD
Assistant Professor
Laboratory medicine
UW

Tuesday, March 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios?

David Wu, MD, PhD
Assistant Professor
Dept. of Laboratory Medicine
UW

Tuesday, March 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium

Local Control of Excitation-Transcription Coupling in Smooth Muscle

Luis Fernando Santana, Ph.D.
Associate Professor
Physiology and Biophysics
UW

Tuesday, March 10, 2009 - 8:30 AM
Health Sciences Building, K-069

uPA-accelerated atherosclerosis and plaque rupture: searching for mechanisms

Jie Hong Hu, Ph.D.
Senior Fellow
Division of Cardiology
UW

Tuesday, March 3, 2009 - 8:30 AM
Health Sciences Building, K-069

TLR in Lung Ischemia Reperfusion InjuryTLR in Lung Ischemia Reperfusion Injury

John C. Keech, M.D.
Postdoctoral Fellow
Surgery
UW

Tuesday, February 24, 2009 - 8:30 AM
Health Sciences Building, K-069

Myofilament Regulation of the Frank-Starling Law of the Heart

F. Steven Korte, Ph.D.
Senior Fellow
Bioengineering
UW

Tuesday, February 17, 2009 - 8:30 AM
Health Sciences Building, K-069

The FGF Axis: New Therapeutic Opportunities

Norman M. Greenberg, Ph.D.
Member, Clinical Research Division, Fred Hutchinson Cancer Research Center; Professor of Pharmacology, University of Washington
FHCRC and UW

Tuesday, February 10, 2009 - 8:30 AM
Health Sciences Building, K-069

Tracking the Human Kineome and Phosphoproteins for Biomarker Discovery with Protein Microarrays

Steven Pelech, Ph.D.
President and Chief Scientific Officer, Kinexus Bioinformatics Corporation; Professor, Division of Neurology, Dept. of Medicine, University of British Columbia
Kinexus Bioinformatics Corp. and Univ. of British Columbia

Tuesday, February 3, 2009 - 8:30 AM
Health Sciences Building, K-069

SMC plasticity and reprogramming in calcifying vasculature

Yanfeng (Mei) Speer, Ph.D.
Research Assistant Professor
Bioengineering
UW

Tuesday, January 27, 2009 - 8:30 AM
Health Sciences Building, K-069

Genome Regulation During Cardiac Mesoderm Directed Differentiation of Human Embryonic Stem Cells

Jonathan Golob
Graduate Student
Pathology
UW

Tuesday, January 13, 2009 - 8:30 AM
Health Sciences Building, K-069

AAV vectors: biology and utility for gene addition and gene correction

David Russell, MD, PhD
Professor of Medicine
Div. of Hematology
UW

Tuesday, January 6, 2009 - 8:30 AM
Health Sciences Building, K-069

Cockayne syndrome, chromosome fragility, and piggyBac transposons that are good for you

Alan Weiner, PhD
Professor and ZymoGenetics Chair
Biochemistry
UW

Tuesday, December 16, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium

A-type nuclear lamins in aging and disease

Brian Kennedy, PhD
Associate Professor
Biochemistry
UW

Tuesday, December 9, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium

Delta 1: A Notch up on cord blood stem cell transplantation

Irwin Bernstein, MD
Hartmann Professor and Head, Division of Pediatric Hematology/Oncology, University of Washington; Member and Head, Pediatric Oncology Program, Fred Hutchinson Cancer Research Center; Clinical Research Professor, American Cancer Society
UW and FHCRC

Tuesday, November 25, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium

Oncogene-induced inflammation: A pathway linking autoimmune disease with cancer

Jay Rothstein, PhD
Director
Inflammation Research
Amgen, Inc., Seattle, WA

Tuesday, November 18, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium

Induction of Cardiac Pacemaker by Neuregulin Blockade and electrophysiological properties of cardios derived from hESCs

Wei-Zhong Zhu, PhD
Postdoctoral Fellow
Pathology
UW

Tuesday, November 18, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium

Faculty Sponsor: Michael Laflamme

Epigenetic programming of mesenchymal stem cells

Philippe Collas, PhD
Professor
Institute of Basic Medical Sciences, Dept. of Biochemistry
University of Oslo, Norway

Tuesday, October 21, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium

Faculty Sponsor: Karol Bomsztyk

Regulation of Nodal Signaling by microRNAs

Wen-Yee Choi
Graduate Researcher
Molecular and Cellular Biology
Harvard University

Tuesday, October 14, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium

Faculty Sponsor: Charles Murry

Contribution of interstitial valve cells to valve calcification

Marcello Rattazzi, MD
Clinical and Experimental Medicine
University of Padua, Italy

Wednesday, October 8, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium

Molecular mechanisms of aging: What can we learn from yeast and worms?

Matt Kaeberlein, PhD
Assistant Professor
Pathology
UW

Tuesday, October 7, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium

“Magnetic Resonance Imaging of Gene Expression"

Anna Naumova, Ph.D.
Senior Fellow
Radiology
UW

Tuesday, June 24, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

“Directly targeting myofibrillar proteins to improve cardiomyocyte contraction"

F. Steven Korte, PhD
Senior fellow
Bioengineering
UW

Tuesday, June 17, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

“Fatty Acids and the Renal Complications of Type 2 Diabetes Mellitus”

Bardia Askari, Ph.D.
Acting Instructor
Pathology
UW

Tuesday, June 10, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

“Acceleration of atherosclerosis by type 1 diabetes: Evidence from a mouse model”

Karin E. Bornfeldt, Ph.D.
Professor
Pathology
Medicine

Tuesday, June 3, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer

“Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes”

Charis L. Himeda, Ph.D.
Senior fellow
Biochemistry
UW

Tuesday, May 20, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

“Ex Vivo/In Vivo MRI-based Mechanical Analysis of Human Carotid Atherosclerotic Plaque Vulnerability Assessment”

Dalin Tang, Ph.D.
Professor
Mathematics and Biomedical Engineering
Worcester Polytechnic Institute

Tuesday, May 13, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Chun Yuan, Ph.D.
815 Mercer Street

“Why are there so many isoforms of long-chain acyl-CoA synthetases in arterial smooth muscle cells? Do they have different functions?”

Deidre Golej
Graduate Student, Molecular and Cellular Biology
Pathology
UW

Tuesday, May 6, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

“Diabetic vascular disease: Hitting below the belt”

Kanchan Chitaley, Ph.D.
Research Assistant Professor
Urology
UW

Tuesday, April 29, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

“FLT1 is a malaria resistance gene: hypertension, inflammation and natural selection in utero”

Atis Muehlenbachs
MSTP and Incoming Resident
Pathology
UW

Tuesday, April 22, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

"Transcriptional regulation of thrombin receptors by vasodilator prostaglandins"

Karsten Schror, M.D.
Professor and Chair
Pharmacology and Clinical Pharmacology
Heinrich-Heine-Universitat Dusseldorf

Tuesday, April 15, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Alexander W. Clowes, MD
815 Mercer Street

“A-type nuclear lamins: insights into the striated muscle phenotypes of Lmna-/- mice”

Richard Frock
PhD Candidate
Biochemistry
UW

Tuesday, April 8, 2008 - 8:30 AM
Health Sciences Building, K-069

"I get by with a little help from my friends: The alpha1D-adrenergic receptor/dystrophin signalosome regulates blood pressure"

Chris Hague, Ph.D.
Assistant Professor
Pharmacology
UW

Tuesday, April 1, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

"Beyond Transcription: Translational Regulation During Embryonic Stem Cell Differentiation"

Prabha Sampath, Ph.D.
Postdoctoral Fellow
Pathology
UW

Tuesday, March 25, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

“Functional correction of muscles and extension of lifespan in dystrophic mice via AAV gene transfer”

Jeffrey S. Chamberlain, Ph.D.
Professor
Depts. of Neurology, Medicine and Biochemistry
UW

Tuesday, March 18, 2008 - 8:30 AM
HSB, T-635

"The Road to Resolution: Role of IGF Pathway in Lung Injury and Repair"

Lynn M. Schnapp, M.D.
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
UW

Tuesday, March 4, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

"Proteolytic shedding of cell surface proteins as a gatekeeper for leukocyte trafficking to and from inflammatory sites"

Elaine W. Raines
Research Professor
Pathology
UW

Tuesday, February 12, 2008 - 8:30 AM
HSB, K-069

“The Role of Filamin in Transcriptional Control of Laminin Expression”

Christine K. Abrass, MD, FACP
Professor of Medicine
Division of Gerontology and Geriatric Medicine
UW

Tuesday, February 5, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

"Encapsulated vascular smooth muscle cells to treat rat models of diabetes"

William Osborne, PhD
Research Professor
Pediatrics
UW

Tuesday, January 29, 2008 - 8:30 AM
HSB, K-069

“Stabilizing the atherosclerotic plaque: taming the CD40-CD40L system”

Esther Lutgens, MD, PhD
Associate Professor
Pathology
CardioVascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands

Tuesday, January 22, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Michael Rosenfeld, PhD
815 Mercer Street

"Cre-loxP Technology: a Lineage Tracing Study of Osteochondrogenic Cells in Calcifying Vasculature"

Yanfeng (Mei) Speer, PhD
Research Assistant Professor
Bioengineering
UW

Tuesday, January 15, 2008 - 8:30 AM
HSB, K-069

TBA

Roger E. Bumgarner, PhD
Associate Professor
Microbiology
UW

Tuesday, December 18, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

"Innate immune recognition and response to microbial pathogens"

Kelly Smith, MD, PhD
Assistant Professor
Pathology
UW

Tuesday, December 11, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

Macrophage Mediators of Cardiac Fibrosis

April S. Stempien-Otero, MD
Assistant Professor of Medicine
Cardiology
UW

Tuesday, December 4, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

"Lung Injury and Repair: Inflammation, apoptosis and the Fas/FasL system"

Gustavo Matute-Bello, MD
Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
UW

Tuesday, November 27, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

"Mitochondria, lifespan and the aging heart"

Peter S. Rabinovitch, M.D., Ph.D.
Professor
Pathology
UW

Tuesday, November 20, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

"Human Embryonic Stem Cell Niches?"

C. Anthony Blau, MD
Professor of Medicine
Hematology
UW

Tuesday, November 13, 2007 - 8:30 AM
Brotman Building, 815 Mercer Street, SLU Auditorium

"Pathology of human graft- versus host disease after hemopoietic cell transplantation: Implications for studies of the vascular system"

Howard M. Shulman, M.D.
Professor
Pathology/Oncology
FHCRC

Tuesday, November 6, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

"Pragmatic Extracellular Matrices for Cell Therapy and Reparative Medicine"

Glenn D. Prestwich, Ph.D.
Presidential Professor of Medicinal Chemistry
Department of Medicinal Chemistry and Center for Therapeutic Biomaterials
The University of Utah

Tuesday, October 30, 2007 - 8:30 AM
SLU - Brotman Bulding, Blue Flame Auditorium

Faculty Sponsor: Thomas N. Wight, Ph.D.
815 Mercer Street

Ribosomes and Spindles in Marrow Failure and Cance Predisposition

Akiko Shimamura, MD
Associate Professor of Pediatrics
Division of Hematology/Oncology
UWSOM

Tuesday, October 16, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street

Leptin in Cardiovascular Disease

Daniel Eitzman
Assistant Professor
Internal Medicine/Cardiovascular Disease
University of Michigan

Wednesday, September 26, 2007 - 8:30 AM
Brotman Building, SLU, Blue Flame

Faculty Sponsor: Steve Schwartz
815 Mercer Street Reschedule - date tentative

Insulin Modulation of Plasma beta-Amyloid levels

Pattie S. Green, PhD
Research Assistant Professor
Medicine
UWSOM

Tuesday, June 26, 2007 - 8:30 AM
TBA, TBA

Faculty Sponsor: Renee LeBoeuf

TBA

Larry Adams
Senior Research Scientist
Pathology
UWSOM

Tuesday, June 19, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street

RGS5: Regulating the Regulator

William M. Mahoney Jr.
Postdoctoral Fellow
Pathology
UWSOM

Tuesday, June 5, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Steve Schwartz
815 Mercer Street

How does mechanical force activate adhesion proteins, and what does this have to do with cardiovascular disease?

Wendy Thomas
Assistant Professor
Bioengineering
UWSOM

Tuesday, May 29, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

Molecular Mechanisms of Regulation of L-type Calcium Channels

Michelle Emrick
Senior Fellow
Pharmacology
UWSOM

Tuesday, May 22, 2007 - 8:30 AM
Health Sciences, K-069

TGF-beta signaling in kidney cells

Anne-Christine Poncelet
Acting Instructor
Medicine-Gerontology
UW School of Medicine

Tuesday, May 15, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street

AAV6-mediated Systemic Expression of alpha-Dystrobrevin-3 Prevents Muscular Dystrophy in alpha-Dystrobrevin Null Mice

Guy Odom
Senior Fellow
Neurology
UWSOM

Tuesday, May 8, 2007 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: David Dichek

The role of P2X7 and activated caspases in the regulation of macrophage fusion

Thomas Nhan
PhD Candidate
Pathology
UW School of Medicine

Tuesday, May 1, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Steve Schwartz
815 Mercer Street

Using Chemical-Genetics to Reversibly Inhibit Protein Kinase A: Implications for Male Reproduction

Daniel J. Morgan
Senior Fellow
Pharmacology
UWSOM

Tuesday, April 17, 2007 - 8:30 AM
Health Sciences, K-069

Faculty Sponsor: Steve Schwartz

Regulation of Angiogenesis by the OPG/RANKL/RANK Molecular Triad

Joseph McGonigle
Research Assistant
Bioengineering
UWSOM

Tuesday, April 10, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Cecilia Giachelli
815 Mercer Street

Understanding macrophage foam cell formation using a proteomics-based approach

Lev Becker
Senior Fellow
Medicine, Division of Metabolism, Endocrinology and Nutrition
UWSOM

Tuesday, April 3, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Jay Heinecke
815 Mercer Street

Probing chromatin dynamics

Karol Bomsztyk
Professor
Medicine
UWSOM

Tuesday, March 27, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street

Angiotensin II-induced vascular pathologies - a multitude of mechanisms

Alan Daugherty
Professor
Cardiovascular Medicine
University of Kentucky

Tuesday, March 20, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Mike Rosenfeld
815 Mercer Street

A ROCK and Role for Syndecans in Cytoskeletal Regulation

John R. Couchman
Professor
National Heart & Lung Institute
Imperial College, London

Tuesday, March 13, 2007 - 8:30 AM
Brotman Building (SLU), Blue Flame Auditorium

Faculty Sponsor: Bill Parks
815 Mercer Street

Loss of capillaries and vascular phenotype in Systemic Sclerosis, does autologous stem cell transplant regenerate capillaries?

Jo Fleming
Scleroderma Research Fellow
Pathology
UWSOM

Tuesday, March 6, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Steve Schwartz
815 Mercer Street RESCHEDULED!

Chromatin Remodeling During Mouse and Human Embryonic Stem Cell Differentiation

Jonathan Golob
Graduate Student
Pathology
UWSOM

Tuesday, February 27, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Chuck Murry
815 Mercer Street

Adult Stem Cells: Epigenetics, pluripotency and plasticity

Morayma Reyes
Assistant Professor
Pathology and Laboratory Medicine
UWSOM

Tuesday, February 13, 2007 - 8:30 AM
SLU, Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Steve Schwartz
815 Mercer Street

Role of macrophage-expressed urokinase plasminogen activator (uPA) in atherosclerosis

Ranjini M. Krishnan
Fellow
Cardiology
UWSOM

Tuesday, February 6, 2007 - 8:30 AM
Health Sciences, K-069

Faculty Sponsor: David Dichek

Monocytes, Dendritic Cells, and Atherosclerosis

Gwen Randollph
Associate Professor
Gene & Cell Medicine
Mt. Sinai School of Medicine

Tuesday, January 30, 2007 - 10:00 AM
Health Sciences, K-069

Faculty Sponsor: Elaine Raines/Stephen Schwartz
Jointly Sponsored by Breakfast Club and Biology of the Artery Wall Program Project

Magnetic Resonance Imaging of Atherosclerosis

Hunter R. Underhill
Fellow
Vascular Imaging Lab
UWSOM

Tuesday, January 23, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street

Caspase regulation of macrophage functions

Thomas Q. Nhan
PhD Candidate
Pathology
UWSOM

Tuesday, January 16, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Steve Schwartz
815 Mercer Street

Tissue voxelation with a high-speed transverse microtome

John Welsh, PhD
Associate Professor
Molecular and Cancer Biology Program
Sidney Kimmel Cancer Center, San Diego, California

Tuesday, January 9, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Marshall Horwitz
815 Mercer Street

Molecular Profiling of Circulating Monocytes in Carotid Artery Atherosclerotic Disease

Hangjun Duan
Senior Fellow
Pathology
UWSOM

Tuesday, December 19, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Steve Schwartz
815 Mercer Street

BTNL2, a novel B7 family member and regulator of T cell activation

Heather Arnett
Scientist
Amgen, Inc.

Tuesday, December 5, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Steve Schwartz
815 Mercer Street

The Ins and Outs of Bcl-2 in Cell Death

John M. Harlan, MD
Chief
Clement A. Finch Professor of Hematology, Adjunct Professor of Pathology
University of Washington

Tuesday, November 21, 2006 - 8:30 AM
Health Sciences Building, K-069

TSLP and Th2-mediated inflammation

Steven F. Ziegler, PhD
Director
Immunology Program
Benaroya Research Institute

Tuesday, November 14, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Steve Schwartz
815 Mercer Street

Differentiation of Endothelium from Human Embryonic Stem Cells

Marilyn Nourse
PhD Candidate
Pathology
UWSOM

Tuesday, November 7, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium

Faculty Sponsor: Chuck Murry
815 Mercer Street

Type 1 diabetes promotes inflammation and disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice

Fredrik Johansson
Postdoctoral Fellow
Pathology
UWSOM

Tuesday, October 31, 2006 - 8:30 AM
Health Sciences, K-069

Faculty Sponsor: Karin Bornfeldt

Calcium Sparklets in Vascular Smooth Muscle

Manuel F. Navedo
Senior Fellow
Physiology and Biophysics
UWSOM

Tuesday, October 24, 2006 - 8:30 AM
Health Sciences Building, K-069

Cancelled will reschedule for spring

David Lovett - postponed
Professor in Residence
Medicine, Division of Nephrology, Fort Miley Veterans Admin Hospital
University of California, San Francisco

Tuesday, October 17, 2006 - 8:30 AM
TBA, TBA

PSGL-1 Adherence and mTOR Modulate Translation in Macrophages

Richard Fox
PhD Candidate
Pathology
UW School of Medicine

Tuesday, October 10, 2006 - 8:30 AM
Brotman Building (SLU), Blue Flame Auditorium

Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street

An unexpected role for the tissue factor pathway in atherosclerosis

Robert D. Simari
Professor
Cardiovascular Diseases
Mayo Clinic

Tuesday, October 3, 2006 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: David Dichek

Of mice and mice; why some do and some don't develop arterial lesions

Michael A Reidy PhD
Professor
Pathology
UWSOM

Tuesday, September 26, 2006 - 8:30 AM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street

The rupture-prone human plaque: how to define and detect it

Erling Falk
Professor
Department of Cardiology
Skejby University Hospital, Aarhus, Denmark

Tuesday, June 27, 2006 - 8:30 AM
SLU 815 Mercer Street, 111

Faculty Sponsor: Steve Schwartz

Protection of cardiovascular stem cells by cholesterol-lowering therapy

Yong-Jian Geng, MD PhD
Professor & Director Center for Cardiovascular Biology and Atherosclerosis Research
Dept. of Internal Medicine, Cardiology Division
University of Texas School of Medicine, Houston, TX

Tuesday, June 20, 2006 - 8:30 AM
SLU 815 Mercer Street, 111

Faculty Sponsor: Chuck Murry

Distinct Wnt signaling pathways play opposing roles during organ regeneration

Cristi Stoick-Cooper
CVP Graduate Student
Neurobiology & Behavior
UWSOM

Tuesday, May 30, 2006 - 8:30 AM
HSB, K-069

Using Kinase Chemical Genetics as a Novel Tool to Investigate Heart Disease

Daniel J Morgan
Senior Fellow
Pharmacology
UWSOM

Tuesday, May 23, 2006 - 8:30 AM
Health Sciences, K-069

Faculty Sponsor: Stephen M Schwartz

Cardiac applications for human embryonic stem cells

Michael Laflamme
Acting Instructor
Pathology
Center for Cardiovascular Biology & Regenerative Medicine, UWSOM

Tuesday, May 2, 2006 - 8:30 AM
SLU 815 Mercer St, 111

Faculty Sponsor: Chuck Murry

Inflammation loci and carotid artery disease

Gail Jarvik MD
Professor
Medicine, Medical Genetics
UWSOM

Tuesday, April 25, 2006 - 8:30 AM
SLU 815 Mercer, 111 Auditorium

Faculty Sponsor: Stephen M Schwartz

Proteomic Analysis of the Cardiac Calcium Channel

Michelle Emrick PhD
Senior Fellow
Pharmacology
UWSOM

Tuesday, April 18, 2006 - 8:30 AM
HSB, K-069

Faculty Sponsor: Stephen M Schwartz

The Role of Pattern Recognition Receptors in Macrophage Death

Ira Tabas, MD/PhD
Professor, Medicine and Anatomy & Cell Biology
Deputy Editor - Journal of Clinical Investigation
Columbia University

Tuesday, April 11, 2006 - 8:30 AM
SLU 815 Mercer Street, 111

Faculty Sponsor: Michael Rosenfeld

Evolutionary genetics, genomics, and genetic networks: How should we approach the genetic foundations of the evolution of development/morphology?

Adam S. Wilkins
Editor, BioEssays
Company of Biologists, Ltd.
Cambridge, UK

Tuesday, April 4, 2006 - 8:30 AM
SLU 815 Mercer Street, 111

Faculty Sponsor: Karol Bomsztyk

Regulatory T cells, TGF-beta and atherosclerosis

Goran K. Hansson
Professor
Cardiovascular Research, Molecular Medicine
Karolinska Institutet, Stockhom, Sweden

Tuesday, March 28, 2006 - 8:30 AM
SLU 815 Mercer Street, 111

Faculty Sponsor: Stephen M. Schwartz

Structure Biology of Ubiquitin Ligase Machinery

Ning Zheng
Assistant Professor
Pharmacology
UWSOM

Tuesday, March 21, 2006 - 8:30 AM
Health Sciences Building, K-069

Atheroprotective Effects of Transforming Growth Factor Beta-1

Andrew D. Frutkin, MD
Acting Instructor/Senior Fellow
Cardiology Division
UWSOM

Tuesday, March 14, 2006 - 8:30 AM
SLU 815 Mercer Street, 111

Faculty Sponsor: David Dichek
Please note change of venue

The CD4+ autoreactive T cell: chance or necessity?

Gerald T. Nepom, MD/PhD
Director
Benaroya Research Institute at Virginia Mason

Tuesday, March 7, 2006 - 8:30 AM
SLU 815 Mercer Street, 111

C-reactive protein and cardiovascular risk: a population genomics approach

Alex Reiner, MD MSc
Research Associate Professor
Epidemioloy & Laboratory Medicine
UWSOM

Tuesday, February 28, 2006 - 8:30 AM
SLU 815 Mercer, 111

Faculty Sponsor: Stephen M. Schwartz

Clinical Genetics and Genomics of Type I Collagen

Peter Byers, MD
Professor
Pathology & Medicine
UWSOM

Tuesday, February 21, 2006 - 8:30 AM
Health Sciences, K-069

Wnt pathways can control cardiogenesis in mouse embryonic stem cells

Shuichi Ueno, MD/PhD
Senior Fellow
Pathology
UWSOM

Tuesday, February 14, 2006 - 8:30 AM
Health Sciences, K-069

Faculty Sponsor: Chuck Murry

The TGF-beta/Smad Pathway and its Implications in Regulating Fibroblast and Malignant Melanocyte Functions

Alain Mauviel, PhD
Director
INSERM U697
Hospital Saint-Louis, Paris, France

Tuesday, February 7, 2006 - 8:30 AM
South Lake Union, 111

Faculty Sponsor: Bill Parks

HnRNP K: Gene expression, hubs and scale-free networks

Karol Bomsztyk
Professor
Medicine
UWSOM

Tuesday, January 31, 2006 - 8:30 AM
Health Sciences Building, K-069

Molecular Basis of Information

Daniel Storm
Professor
Pharmacology
UWSOM

Tuesday, January 24, 2006 - 8:30 AM
HSB, K-069

Faculty Sponsor: Stephen M Schwartz

Retrograde Signaling by Leukemia Inhibitory Factor in Sympathetic Neurons

Jennifer O'Brien
Senior Fellow
Pharmacology
UWSOM

Tuesday, January 17, 2006 - 8:30 AM
HSB, K-069

Faculty Sponsor: Stephen M. Schwartz

Regulation of Nitric Oxide Synthase by Shear Stress

David G. Harrison MD
Professor, Medicine
Director, Division of Cardiology
Emory University School of Medicine

Tuesday, January 10, 2006 - 8:30 AM
South Lake Union (SLU), 111

Faculty Sponsor: Stephen M. Schwartz

Apoptosis and Macrophage Inflammation

Keith Elkon, MD
Prof. of Medicine & Adjunct Prof. Immunology
Head, Division of Rheumatology
UWSOM

Tuesday, December 20, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Stephen M. Schwartz

Mechanisms of Arterial Constriction due to Urokinase Overexpression

Philip Massey, MD
Acting Instructor
Medicine/Cardiology
UWSOM

Tuesday, December 13, 2005 - 8:30 AM
Health Sciences Building, K-069

Myosin Binding Protein-C: A Regulator of Contraction through Thick and Thin

Samantha Harris, PhD
Research Assistant Professor
Bioengineering
UWSOM

Tuesday, December 6, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Cecilia Giachelli

Immunopathogenesis of the Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction Syndrome (MODS)

Conrad Liles
Associate Professor
Medicine, Infectious Diseases
UWSOM

Tuesday, November 29, 2005 - 8:30 AM
SLU 815 Mercer Street, 111

What are the roles of glucose and lipids in diabetes-accelerated atherosclerosis in mice?

Karin Bornfeldt PhD
Associate Professor
Pathology
UWSOM

Tuesday, November 22, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Stephen M. Schwartz

Vascular Calcification: role of smooth muscle cells and phosphate

Cecilia Giachelli PhD
Professor
Bioengineering
UWSOM

Tuesday, November 15, 2005 - 8:30 AM
Health Sciences Building, K-069

N-terminus-dependent ubiquitin pathway: its role in cardiovascular and nervous systems

Yong Tae Kwon
Assistant Professor
Pharmaceutical Sciences
University of Pittsburgh

Thursday, November 10, 2005 - 8:30 AM
Health Sciences Building, T-635

Faculty Sponsor: Stephen M. Schwartz
Special Breakfast Club

Macrophage adherence induces ROCK-1 synthesis via mTOR-mediated translational control

Richard Fox
PhD Candidate
Pathology, Cardiovascular Biology
UWSOM

Tuesday, November 8, 2005 - 8:30 AM
Health Sciences Bldg., K-069

Faculty Sponsor: Stephen M Schwartz

Extracellular Matrix as a Framework for the Innate Immune Response in the Lungs

Charles Frevert, DVM, ScD
Research Associate Professor
Medicine/Pulmonary & Critical Care Medicine
VA Medical Center/UWSOM

Tuesday, November 1, 2005 - 8:30 AM
SLU 815 Mercer Street, 111

Faculty Sponsor: Bill Parks

Role of PAI-1 in Progressive Renal Disease

Allison Eddy, MD
Professor & Head
Division of Pediatric Nephrology
Children's Hospital & Med Center, UWSOM

Tuesday, October 25, 2005 - 8:30 AM
SLU 815 Mercer Street, 111

Faculty Sponsor: Stephen M. Schwartz

Roundtable Discussion: Pathologic implications of vascular developmental biology

Brant Weinstein
Senior Investigator and Head of Section of Vertebrate Organogenesis
Laboratory of Molecular Genetics
NIH National Institute of Child Health & Human Development (NICHD)

Tuesday, October 18, 2005 - 9:30 AM
Health Sciences Building, E-212

Faculty Sponsor: Elaine Raines/Steve Schwartz
Special Breakfast Club. Seating is very limited. RSVP to Sharon at 897-1537 or via e-mail sharon1@u.washington.edu. There will be no refreshments.

Regulation of GPCR Function by RGS

Chris Hague
Assistant Professor
Pharmacology
UWSOM

Tuesday, October 11, 2005 - 8:30 AM
SLU 815 Mercer Street, Auditorium, Rm. 111

Faculty Sponsor: Stephen M. Schwartz

Embracing Complexity, Inching Closer to Reality: Novel Integrative Genomics Strategies to Map Genes for Complex Disease Traits

Eric Schadt, PhD
Senior Scientific Director
Research Genetics
Rosetta Inpharmatics, Inc., Seattle, WA

Tuesday, October 4, 2005 - 8:30 AM
SLU 815 Mercer Street, 111

Faculty Sponsor: Stephen M. Schwartz

Translation control in activated endothelial cells

Larry W. Kraiss MD
Assistant Professor & Chief
Division of Vascular Surgery
University of Utah

Tuesday, September 13, 2005 - 8:30 AM
South Lake Union, 111

Faculty Sponsor: Richard Kenagy

Mitochondrial Damage and Biogenesis in Diabetic Heart and Protection by Overexpression of Manganese Superoxide Dismutase (MnSOD)

Xia (Clare) Shen PhD
Postdoc Candidate
Pharmacology & Toxicology
University of Louisville

Tuesday, July 26, 2005 - 8:30 AM
HSB, K-069

Faculty Sponsor: Karin Bornfeldt
Special Breakfast Club

Expression Profiling of Human Cavernosal Endothelial Cells: A Role For Claudin-11/OSP in the Endothelium?

Chris Sullivan
Postdoctoral Fellow
Urology
UWSOM

Tuesday, July 19, 2005 - 9:00 AM
South Lake Union, 111

Faculty Sponsor: Hunter Wessells

The role of wnt signaling in zebrafish heart development and regeneration

Cristi Stoick
Graduate Student
Neurobiology & Behavior
UWSOM

Tuesday, June 14, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Steve Schwartz

Potassium Channel Regulation in Cerebral Arterial Smooth Muscle

Gregory Amberg
Senior Fellow
Physiology & Biophysics
UWSOM

Tuesday, June 7, 2005 - 8:30 AM
Health Sciences Building, K-069

Aldosterone and cardiovascular disease: past, present and future

Bardia Askari
Acting Instructor
Pathology
UWSOM

Tuesday, May 31, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Steve Schwartz

Non-invasive, quantitative magnetic resonance perfusion measurements in limb skeletal muscle

Kenneth Marro
Research Assistant Professor
Radiology
UWSOM

Tuesday, May 24, 2005 - 9:00 AM
South Lake Union, 100

Faculty Sponsor: Chun Yuan
Please note change of venue to 815 Mercer Street.

Selective Control of Endothelial Cell Proliferation with a Synthetic Dimerizer of the FGF Receptor

Marilyn Nourse
Graduate Student
Bioengineering
UWSOM

Tuesday, May 10, 2005 - 8:30 AM
Health Sciences Building, K-069

Can Endothelial Cells Transdifferentiate into Cardiomyocytes? HUVECs and Developmental Studies

Robert Welikson
Senior Research Fellow
Biochemistry
UWSOM

Tuesday, May 3, 2005 - 8:30 AM
SLU 815 Mercer Street, 100

Faculty Sponsor: Stephen Schwartz
Please note change of venue.

Uncovering the role of receptor trafficking in disease

Matthew Holdren
Graduate Student
Pathology
UWSOM

Tuesday, April 26, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Tony Parks

Can bacteria cause blood vessels to calcify?

Michael Rosenfeld
Professor
Pathobiology and Pathology
UWSOM

Tuesday, April 19, 2005 - 8:30 AM
Health Sciences Building, K-069

Exploring the immunomodulatory action of mechanical ventilation

William A. Altemeier
Assistant Professor
Pulmonary & Critical Care Medicine
UWSOM

Tuesday, April 12, 2005 - 9:00 AM
SLU 815 Mercer Street (Blue Flame), 100

Faculty Sponsor: Conrad Liles
Please note change of venue.

FDR, April 12, 1945

Karol Bomsztyk
Professor
Medicine, Allergy and Infectious Disease
UWSOM, South Lake Union

Tuesday, April 5, 2005 - 8:30 AM
Health Sciences Building, K-069

Integrin Signaling: Grasping the survival mechanisms

Donald Courter
PhD Candidate
Bioengineering
University of Washington

Tuesday, March 29, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Cecilia Giachelli

Hedgehog signaling in angiogenesis

Ronald Heimark PhD
Associate Professor
Surgery, Cell Biology & Anatomy, and Pathology
Arizona Health Sciences Center

Tuesday, March 22, 2005 - 9:00 AM
SLU 815 Mercer Street (Blue Flame), 100

Faculty Sponsor: Stephen M. Schwartz
Please note change of venue.

Vascular malformations and guidance

Dean Li
Faculty Candidate
Medicine, Division of Cardiology
University of Utah

Tuesday, March 15, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: David Dichek

Adaptation of the Developing Cardiovascular System to Changes in Vessel Wall Extracellular Matrix

Robert Mecham
Alumni Endowed Professor Cell Biology and Physiology
Medicine, Pediatrics and Bioengineering
Washington University, St. Louis MO

Tuesday, March 1, 2005 - 9:00 AM
South Lake Union, 815 Mercer Street, 110

Faculty Sponsor: Bill Parks
Please note change of location.

Maternal Cells in Children's Organs: Playing, Working, or Stirring up Trouble

Anne M. Stevens
Acting Assistant Professor
Pediatrics, Division of Immunology/Rheumatology
Children's Hospital and Regional Medical Center

Tuesday, February 22, 2005 - 8:30 AM
Health Sciences Building, K-069

ROCK-1 protein is translationally regulated by mTOR and post-translationally processed in a caspase dependent manner following adherence in macrophage

Richard Fox
Graduate Student
Pathology
University of Washington

Tuesday, February 15, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Stephen M. Schwartz

Hepsins: Lethal giant larvae

Valeri Vasioukhin
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center

Tuesday, February 8, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Bill Parks

Placental malaria and maternal blood pressure

Atis Muehlenbachs
Graduate Student, Concurrent Degree
Molecular & Cellular Biology
UWSOM

Tuesday, February 1, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Dan Bowen-Pope

The Role of PI-3 Kinase in Cardioprotection

Charles Steenbergen, MD PhD
Faculty Candidate
Pathology
Duke University, Durham, NC

Tuesday, January 25, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Chuck Murry

Metalloproteinases: Effectors of Innate Immunity

William C. Parks
Professor
Pulmonary & Critical Care Medicine
UWSOM, Harborview

Tuesday, January 18, 2005 - 8:30 AM
Health Sciences Building, K-069

Roles of TGFbeta1 in preventing autoimmune myocarditis and in stimulating cardiac hypertrophy

Tom Doetschman
Professor of Molecular Genetics
Biochemistry & Micorbiology
University of Cincinnati College of Medicine

Tuesday, January 11, 2005 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: David Dichek/Stephen M. Schwartz

Angiogenesis in Prostate Cancer

Norman M. Greenberg
Professor
Clinical Research
Fred Hutchinson Cancer Research Center

Tuesday, December 14, 2004 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Stephen M. Schwartz

Identification of novel substrates of Matrix Metalloproteinase-9 by proteomics

Tomas Vaisar
Research Scientist
Metabolism, Endocrinology & Nutrition
University of Washington School of Medicine

Tuesday, December 7, 2004 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Elaine Raines

Endothelial Cell Activation and Apoptosis

John M. Harlan
Professor of Medicine
Division of Hematology
University of Washington School of Medicine

Tuesday, November 30, 2004 - 8:30 AM
Health Sciences Building, K-069

Probing the determinants of inter-individual variability in innate immune inflammatory responses

Mark Wurfel
Acting Instructor
Division of Pulmonary and Critical Care Medicine
University of Washington

Tuesday, November 23, 2004 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Tom Martin

Magnetic Resonance Imaging: The Coronary Frontier

Won Yong Kim, MD PhD
MR-Center & Department of Cardiology
Skejby University Hospital, Aarhus Denmark

Tuesday, November 16, 2004 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Stephen M. Schwartz

Pharmacological modulation of medial elastocalcinosis

Pierre Moreau, PhD
Associate Professor
Pharmacology
Universit de Montral

Tuesday, November 9, 2004 - 8:30 AM
Health Sciences Building, K-069

Faculty Sponsor: Cecelia Giachelli

Rapid discovery and validation of accessible tumor targets via prefractionated proteomics and molecular imaging in vivo

Jan E. Schnitzer, MD
Professor Cellular & Molecular Biology
Scientific Director
Sidney Kimmel Cancer Center, San Diego, CA

Tuesday, November 2, 2004 - 8:30 AM
Health Sciences Building, K-069

Identification and Characterization of Cyclic Nucleotide Phosphodiesterases in Monocytes and Macrophages

Andrew Bender
Senior Fellow
Pharmacology
University of Washington School of Medicine

Tuesday, October 26, 2004 - 8:30 AM
Health Sciences Building, K-069

LMNA mutations in progeroid syndromes

Junko Oshima
Research Associate Professor
Pathology
University of Washington

Tuesday, October 19, 2004 - 8:30 AM
Health Sciences Building, K-069

Intersections between apoptosis and inflammation

Gustave Matute-Bello
Assistant Professor
Department of Medicine, Division of Pulmonary & Critical Care
University of Washington
Pulmonary Research Laboratories, VA Puget Sound Health Care System

Tuesday, October 12, 2004 - 8:30 AM
Health Sciences Center, Room K-069

Faculty Sponsor: Tom Martin

Arterial Smooth Muscle Cell Heterogeneity: Role in Atheroma Formation and Restenosis

Giulio Gabbiani
Professor
Departments of Pathology and Immunology
University of Geneva-CMU

Tuesday, October 5, 2004 - 8:30 AM
Health Sciences Center, Room K-069

Faculty Sponsor: Stephen Schwartz

NFATc3-Induced Reductions in Voltage-gated K+ currents After Myocardial Infarction

Rick Rossow
Senior Fellow
Physiology and Biophysics
University of Washington

Tuesday, June 15, 2004 - 8:30 AM
Health Sciences Building, K-069

The Role of Acyl Co-enzyme A Synthetases in Lipid Uptake in Vascular Cells

Bardia Askari
Associate
Howard Hughes Medical Institute
University of Washington

Tuesday, June 8, 2004 - 8:30 AM
Health Sciences Building, K-069

Cytochomes p450 and Cardiac Ischemia/Reperfusion Injury

David Granville
University of British Columbia

Tuesday, May 25, 2004 - 8:30 AM
HSB, K-069

Discovery and Characterization of Novel BMP-Regulated Genes Involved in Zebrafish Vascular Development

Ujwal Pyati
Graduate Student
Biochemistry
University of Washington

Tuesday, May 18, 2004 - 8:30 AM
HSB, K-069

Transplantation of undifferentiated embryonic stem cells leads to teratoma formation in the heart

Jeanette Nussbaum
Graduate Student
Department of Pathology
University of Washington

Tuesday, May 11, 2004 - 8:30 AM
Health Sciences Building, K-069

Modulation of Cerebrovascular Potassium Channel Composition and Function During Hypertension

Gregory C. Amber
Senior Fellow
Physiology and Biophysics
University of Washington

Tuesday, April 27, 2004 - 8:30 AM
HSB, K069

The role of endothelial cells in erectile function and dysfunction

Hunter Wessells
Associate Professor
Urology
University of Washington

Tuesday, April 20, 2004 - 8:30 AM
HSB, K-069

Smooth Muscle Cells and Disease - Insights from Microarray Studies

Eileen Mulvihill
Research Assistant Professor
Pathology
University of Washington

Tuesday, April 13, 2004 - 8:30 AM
Health Sciences Building, K-069

Osteoprotegerin and TRAIL as regulators of endothelial cell survival and angiogenesis

Marta Scatena
Research Assistant Professor
Department of Bioengineering
University of Washington

Tuesday, April 6, 2004 - 8:30 AM
Health Sciences Building, K-069

C1Q-TNF Related Protein-1 (CTRP-1), A Novel Approach to Treating Platelet Thrombosis Without Affecting Hemostasis

Joachim Fruebis
Associate Director, ZymoGenetics, Inc.

Tuesday, March 30, 2004 - 8:30 AM
Health Sciences Building, K-069

Phenotypic Modulation of Smooth Muscle Cells in CalcifiedArteries: an On-and-Off Effect Associated with Culture Environment

Mei Speer
Senior Fellow
Bioengineering
University of Washington

Tuesday, March 23, 2004 - 8:30 AM
HSB, K069

Inflammation and atherosclerosis: Role of serum amyloid A

Alan Chait
Edwin L. Bierman Professor of Medicine
Head, Division of Metabolism,
University of Washington

Tuesday, March 9, 2004 - 8:30 AM
HSB, K069

New Developments in an Integrated Model of Cardiac Function

N.P Smith and P.J. Hunter
Bioengineering Institute
University of Auckland

Tuesday, March 2, 2004 - 8:30 AM
Health Science Building, K069

Faculty Sponsor: James B Bassingthwaighte

TGF-B1 and Atherogenesis: Conditional Transgenic Mouse Models

Andrew Frutkin
Senior Fellow
Cardiology
University of Washington

Tuesday, February 24, 2004 - 8:30 AM
HSB, K069

Functional analysis of RGS5 in vascular smooth muscle

Xi Wang
Senior Fellow
Pathology
University of Washington

Tuesday, February 3, 2004 - 8:30 AM
HSB, K069

Salmonid Cardiac Troponin C: Structural and Functional Studies of a Protein Evolved to Increase Cardiac Calcium Sensitivity

Todd Gillis
Senior Fellow
Bioengineering
University of Washington

Tuesday, January 27, 2004 - 8:30 AM
HSB, K069

Gene transfer to striated muscles using AAV

Jeff Chamberlain
Professor
Neurology
University of Washington

Tuesday, January 20, 2004 - 8:30 AM
HSB, K069

Myocardial Reperfusion Injury

Tim Pohlman
Professor
Surgery
University of Washington

Tuesday, January 13, 2004 - 8:30 AM
HSB, K069

The role of Factor XIII in Hemostasis and Wound Healing

Paul Bishop
Distinguished Fellow
ZymoGenetics

Tuesday, December 16, 2003 - 8:30 AM
Health Sciences, K069

Leukocyte Bcl-2 and ischemia-reperfusion injury

Robert K. Winn
Research Professor
Surgery and Physiology-Biophysics
Harborview Medical Center

Tuesday, December 9, 2003 - 8:30 AM
Health Sciences, K069

Targeting interventions to reduce athero-thrombotic disease: genomics, translational biology and population science

David Siscovick
Professor of Medicine & Epidemiology
Cardiovascular Health Research Unit
University of Washington

Tuesday, December 2, 2003 - 8:30 AM
HSB, K069

Improved Vascular Gene Transfer with a Helper-Dependent Adenoviral Vector

Shan Wen
Acting Instructor
Medicine/Division of Cardiology
University of Washington

Tuesday, November 25, 2003 - 8:30 AM
HSB, K069

Functional Genomic Approaches Towards the Understanding of the Mouse Circadian Clock

John Hogenesch
Program Manager, Genomics
Genomics Institute
Novartis Research Foundation

Tuesday, November 18, 2003 - 8:30 AM
HSB, K069

Impaired Myocardial Insulin Signaling and Cardiac Dysfunction in Diabetes

Dale Abel
Assistant Professor of Medicine and Biochemistry
Division of Endocrinology Diabetes and Metabolism
Investigator: Program in Human Molecular Biology and Genetics, University of Utah School of Medicine

Tuesday, November 4, 2003 - 8:30 AM
HSB, K069

Mechanisms of transforming growth factor-beta1-induced neointimal formation

Goro Otsuka
Senior Fellow
Medicine/Cardiology
University of Washington

Tuesday, October 28, 2003 - 8:30 AM
HSB, K069

Tropomyosin Isoform and the Sensitivity of Contractile Mechanics to Strong Actomyosin Crossbridge Binding

Emilie Clemmens
Graduate Student (Defense date Oct. 7th)
Bioengineering
University of Washington

Tuesday, October 21, 2003 - 8:30 AM
HSB, K069

Natural antibodies protect against atherogenesis

Gregg Silverman
Professor in Medicine
Dept. of Medicine
UCSD

Tuesday, October 14, 2003 - 8:30 AM
HSB, K069

Thyroid Hormone and Cardiac Metabolism

Michael Portman
Professor of Pediatrics
Children's Hospital and Regional Medical Center
University of Washington, Division of Cardiology

Tuesday, October 7, 2003 - 8:30 AM
Health Science Buidling, K069

Cardiovascular Genomics: Clinical Implications

Gary H. Gibbons, M.D
Cardiovascular Research Institute
Morehouse School of Medicine

Monday, June 23, 2003 - 8:30 AM
Health Sciences Building, K069

"Links between contractile and electrical dysfunction in heart"

Jeffrey E. Saffitz, M.D., Ph.D.
Lacy Professor of Pathology
Department of Pathology and Immunology
Washington University School of Medicine

Thursday, June 19, 2003 - 10:00 AM
Health Sciences Building, K069

Integrative signaling in angiogenesis

Michael Simons
A. G. Huber Professor of Medicine & Chief of Cardiology
Medical School
Dartmouth

Tuesday, June 10, 2003 - 8:30 AM
Health Sciences Building, T747

Regional Cardiac Sympathetic Dysfunction in CHF

James Caldwell, MD
Professor
Medicine
VA Medical Center

Tuesday, May 20, 2003 - 8:30 AM
Health Sciences Building, K069

Quantitative proteomics: new technology and applications

Reudi Abersold
Professor and Co-founder of the Institutes for Systems Biology
The Institute for Systems Biology

Tuesday, May 6, 2003 - 8:30 AM
HSB, K069

Marrow Derived Stem Cells- What do we really know?

Beverly J Torok-Storb
Member & Associate Program Head Transplantation Biology Program
Fred Hutchinson Cancer Research Center

Tuesday, April 29, 2003 - 8:30 AM
HSB, K069

TBA

Marsha Whitney
Graduate Student
Bioengineering
University of Washington

Tuesday, March 18, 2003 - 8:30 AM
HSB, K069

TBA

Lisa Tannock
Acting Instructor/Senior Fellow
Division of Metabolism, Endocrinology and Nutrition
University of Washington

Tuesday, March 4, 2003 - 8:30 AM
HSB, K069

TBA

Joe Beavo/ Sergei Rybalkin
Professor/ Acting Instructor
Pharmacology
University of Washington

Tuesday, February 18, 2003 - 8:30 AM
HSB, K069

TBA

Joanne Hulme
Senior Fellow
Pharmacology
University of Washington

Tuesday, February 11, 2003 - 8:30 AM
HSB, K069

TBA

Jin-Yong Hwang, M.D. (Visiting Scientist)
Assitant Professor
Department of Medicine
Gyeongsang National University, Republic of South Korea

Tuesday, January 21, 2003 - 8:30 AM
HSB, K069

TBA

Themis Kyriakides
Research Assistant Professor
Biochemistry
University of Washington

Tuesday, January 14, 2003 - 8:30 AM
HSB, K069

Delta1: A Notch Up on Hematopoietic Stem Cell Expansion

Irwin Bernstein
Professor
FHCRC

Tuesday, December 17, 2002 - 8:30 AM
HSC, K-069

"A Genetic Approach to Understanding Basement Membrane Assembly"

Mats Paulsson
Professor of Biochemistry
School of Medicine
University of Cologne

Tuesday, December 3, 2002 - 8:30 AM
HSC, K-069