c.3259-3262delCAAA

 

c.3259-3262delCAAA

Mutation Description

This mutation consists of the deletion of CAAA from c.3259-3262 in exon 25.

Mutation Effect

This mutation results in a frameshift, causing the addition of 10 new amino acids after GLN1010 followed by premature termination and a predicted 1020 residue protein.

Sequence context

ThrGlyLysAspGlnThrGluSerTrpTrpLysAla > ThrGlyLysAspGlnArgValGlyGlyArgLeuPheProValSerTer
ACTGGCAAGGATCAAACAGAGAGTTGGTGGAAGGCT > ACTGGCAAGGATCAGAGAGTTGGTGGAAGGCTTTTTCCCGTCAGCTGA

Cell line and pedigree information

CWW

Reference

  • Moser, M. J., et al. Cancer Res. In press. (2000)

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