-Werner syndrome- a genetic disease that mimics premature aging

Useful information about Werner syndrome and the WRNgene WS International Registry This site contains diagnostic criteria for WRN and contact information for a central repository of WS data and research and materials. WRN Mutation Database A compilation of WS associated WRN mutations

Werner Syndrome (WS) is an uncommon, autosomal recessive human genetic disease that mimics premature aging. Patients with WS appear to age rapidly following puberty, and are at increased risk of developing cancer and cardiovascular disease. Symptoms of WS include premature graying and loss of hair, bilateral cataracts, osteoporosis, atherosclerosis, diabetes and scleroderma-like changes and ulceration of the skin

This UW Werner Syndrome Research Web Site was designed and constructed by Mike Moser supported by NIA Training Grant T32 AG00057 from the Nathan Shock Center of Excellence in the Basic Biology of Aging with assistance from Alden F.M. Hackmann, Ted Holtzman and Joe Don Heath, using input from George Martin, Ray Monnat and Junko Oshima as well as from published references.

[Werner homepage] [WS International Registry] [WRN mutation database] [WRN Forms]