The Table below is a compilation of open reading frame polymorphisms that have been identified in the human WRN gene. These are indicated by position and have been cross-referenced in the form of links to the NCBI dbSNP Database, the University of Washington Genome Center and to published sources.
| cDNA Position* | dbSNP rs# | UW Genome Center** | Exon | Amino Acid | Nucleotide Change | Amino Acid Change |
| c.270G>A | -- | -- | 2 | 13 | G>A | Arg>Arg |
| c.273A>G | rs3087420 | wrn-e2+t55 | 2 | 14 | A>G | Lys>Lys |
| c.326A>G | -- | -- | 2 | 32 | A>G | Lys>Arg |
| c.501T>C | -- | -- | 4 | 90 | T>C | Asn>Asn |
| c.571G>A | rs4987236 | -- | 4 | 114 | G>A | Val>Ile |
| c.678A>T | -- | -- | 5 | 149 | A>T | Arg>Arg |
| c.744T>C | rs2725349 | wrn-e6+f9 | 6 | 171 | T>C | Cys>Cys |
| c.745A>C | -- | -- | 6 | 172 | A>C | Thr>Pro |
| c.951T>G | -- | -- | 7 | 240 | T>G | Asn>Lys |
| c.1201A>G | rs1800390 | -- | 9 | 324 | A>G | Thr>Ala |
| c.1379T>G | rs4987238 | -- | 9 | 383 | T>G | Leu>Trp |
| c.1386A>G | rs2230010 | -- | 9 | 385 | A>G | Glu>Glu |
| c.1392G>A | rs1800391 | -- | 9 | 387 | G>A | Met>Ile |
| c.2402A>T | -- | -- | 19 | 724 | A>T | Gln>Leu |
| c.2592T>G | rs1800392 | wrn-e20+f88 | 20 | 787 | T>G | Leu>Leu |
| c.2691T>G | rs1800393 | -- | 21 | 820 | T>G | Ala>Ala |
| c.2731C>T | rs3087425 | wrn-e21+f52 | 21 | 834 | C>T | Arg>Cys |
| c.2802T>C | rs3087432 | wrn-e21+t60 | 21 | 857 | T>C | Arg>Arg |
| c.3453T>G | rs2725362 | wrn-e26+t12 | 26 | 1074 | T>G | Phe>Leu |
| c.3467C>T | rs3087414 | wrn-e27+f3 | 27 | 1079 | C>T | Ser>Leu |
| c.4036A>G | -- | -- | 32 | 1269 | A>G | Lys>Glu |
| c.4314C>T | rs1801196 | wrn-e34+f101 | 34 | 1361 | C>T | Ser>Ser |
| c.4330T>C | rs1346044 | wrn-e34+t93 | 34 | 1367 | T>C | Cys>Arg |
| c.4447C>T | -- | -- | 35 | 1406 | C>T | Arg>Stop |
| c.4544A>G | -- | -- | 35 | After Stop Codon | A>G | ~ |
*The cDNA position is based on numbering from the start codon and is internally consistent with the UW Genome Center. The numbering starts with 1 at the A of the start codon. This position corresponds to nucleotide position 789 in the NCBI cDNA sequence. NM_000553
**This is a listing of the data that correlate with our exon variants. For the full listing go to the UW Genome Center listing
1. Castro, E., et al. AM J Med Genet. 82:399-403 (1999)