Scholarly book chapters (peer-reviewed)
1. Mishur, R. J., Butler, J. A., & Rea, S. L. Exometabolomic Mapping of Caenorhabditis elegans – A Tool to Non-Invasively Investigate Aging.Meth. Mol. Biol., 1048: 195-213 (2013). PMID: 23929107
2. Henderson S. T., Rea S. L., Johnson T. E. (2006), Dissecting the Processes of Aging Using the Nematode Caenorhabditis elegans. Handbook of the Biology of Aging, 6th Edition. (Eds. Masoro E. J. & Austad, S.N.). Academic Press, London.
Journal articles (peer-reviewed)
3. Kar A., Beam H., Borror M.B., Luckow M., Gao X., Rea S.L.. CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in aSaccharomyces cerevisiae Model System. PLoS One, 11(9). doi:10.1371/journal.pone.0162165. PMID 27603010, (2016)
4. Munkácsy, E.,.†, Khan, M. H.†, Lane R. K., Borror, M. B., Park, J. H., Bokov, A. F., Fisher, A. L. Link, C. D., Rea, S. L. DLK-1, SEK-3 and ¬¬PMK-3 Are Required For The Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genetics, 12, e1006133 († equal contribution), (2016)
5. Mishur, R. J.†, Khan, M. H.†, Munkácsy, E., Bokov, A. F., Sharma, L., Beam, H., Lane, R. Borror, M., Bai, Y., Rea, S. L. Mitochondrial Metabolites Extend Lifespan. Aging Cell. Jan 5. doi: 10.1111/acel.12439. PMID: 26729005. († equal contribution) (2016)
6. Lane, R. K.†, Hilsabeck, T.†, Rea, S.L. The role of mitochondrial dysfunction in age-related diseases. Biochim. Biophys. Acta. Nov; 1847(11): 1387-400. PMID: 26050974. († equal contribution) (2015)
7. Shim, E., Livi, C., Rakheja, D., Tan, J., Benson, D., Parekh, V., Kho, E-Y., Ghosh, A., Kirkman, R., Velu, S., Dutta, S., Chenna, B., Rea, S.L., Mishur, R., Johnson-Pais, T., Li, Q., Guo, L., Bae, S., Wei, S., Block, K., and Sudarshan, S. L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer. Cancer Discovery (2014);4(11):1290-8.
8. Munkácsy E. & Rea, S. L. The Paradox of Mitochondrial Dysfunction and Extended Longevity. Exp. Gerontol., Apr 1. pii: S0531-5565(14)00088-6. (2014).
9. Khan, M. H., Temmer, L., Ligon, M., Hufnal, B., Farber II, R., Munkacsy, E., Dillow, A., Kahlig, E., Rodriguez, A., Rea, S.L. TAF-4 is Required for the Life Extension of isp-1, clk-1 and tpk-1 Mit Mutants. Aging 10, 741-758. (2013) PMCID: PMC3838777
10. Butler, J. A., Mishur, R. J., Bhaskaran, S., & Rea, S. L. A Metabolic Signature for Long Life in the C. elegans Mit Mutants. Aging Cell12(1):130-138. (2013). PMCID: 3552119.
11. Schiavi, A., Torgovnick, A., Kell, A., Megalou, E., Castelein, N., Guccini, I., Marzocchella, L., Gelino, S., Hansen, M., Malisan, F., Condo, I., Bei, R., Rea, S. L., Braeckman, B.P., Tavernarakis, N., Testi, R., Ventura, N. Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans. Experimental Gerontology 48(2):191-201. (2012). PMID: 23247094.
12. Butler, J. A.†, Mishur, R. J.†, Bokov, A. F., Hakala, K. W., Weintraub, S. T., & Rea, S. L. Using GC-MS Metabolomics to Profile the Anaerobic Response of C. elegans. PLoS One7(9):e46140. (†equal contribution). (2012). PMCID: PMC3459875.
13. Khan MH, Hart MJ, Rea SL. The role of MAP4K3 in lifespan regulation of Caenorhabditis elegans. Biochem. Biophys. Res. Commun. PMID: 22846570. (2012). PMID: 22846570.
14. Bhaskaran S., Butler J., Fassio V. Becerra S., Girotti M., Rea S.L. Breaking C. elegans The Easy Way Using The Balch Homogenizer – An Old Tool For a New Application. Analytical Biochemistry (2011). PMID: 21354098.
15. Mishur, R. J., Rea S. L. Applications of Mass Spectrometry to Metabolomics and Metabonomics: Detection of Biomarkers of Aging and of Age-Related Diseases. Mass Spectrometry Reviews (2011) PMID: 21538458.
16. Butler, J.A., Ventura, N., Johnson T.E., Rea S.L. The Long-Lived Mitochondrial (Mit) Mutants of C. elegans Utilize a Novel Metabolism.FASEB J. 24, 4977-4988. (2010)
17. Rea S.L., Kar A., Graham B.H., Nakamuro-Ogiso E., Falk M.J. Bacteria, Yeast, Worms, and Flies: Exploiting simple model organisms to investigate human mitochondrial diseases. Dev. Disabil. Res. Rev. (2010)
18. Wu D., Rea S.L., Cypser J.R., Johnson T.E. Mortality in C. elegans: Remembrance of conditions past. Aging Cell 8, 666-75. (2009)
19. Ventura N., Rea S.L., Schiavi A., Torgovnick A., Testi R., Johnson T.E. p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell 8, 380-393 (2009)
20. Kahn, N.W. Rea, S. L., Moyle, S., Kell, A., Johnson. T.E. Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Biochem J. Jan 1;409(1):205-13. (2008)
21. Rea S.L.†,Ventura N.†, Johnson T.E. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol. Oct 2;5(10):e259. († equal contribution) (2007)
22. Ventura N†, Rea S.L.†. Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. Biotechnol J. May;2(5):584-95. († equal contribution) (2007)
23. Ventura N, Rea S.L., Henderson ST, Condo I, Testi R, Johnson TE. C. elegans as a model for Friedreich Ataxia. FASEB J. May;20(7):1029-30. (2006)
24. Wu D, Rea S.L., Yashin AI, Johnson TE. Visualizing hidden heterogeneity in isogenic populations of C. elegans. Experimental GerontologyMar;41(3):261-70. (Epub 2006 Feb 9). (2006)
25. Ventura N., Rea S.L., Testi R. Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases.Experimental Gerontology Oct;41(10):974-91. Epub 2006 Sep 1. (2006)
26. Rea, S.L.†, Wu, D.†, Cypser, J.R., Vaupel, J.W., Johnson, T.E. A Stress-Sensitive Reporter Predicts Longevity in Isogenic Populations of Caenorhabditis elegans. Nature Genet. 37 (8): 894-898. Epub 2005 Jul 24. († equal contribution) (2005)
27. Rea, S.L. Metabolism in the Caenorhabditis elegans Mit Mutants. Exp. Geront. 40 (11): 841-849. (2005)
28. Ventura N., Rea S., Henderson S.T., Condo I., Johnson T.E. Testi R. Reduced Expression of Frataxin Extends the Life Span of Caenorhabditis elegans. Aging Cell Apr;4(2):109-12. (2005)
29. Rea S., Johnson T.E. A metabolic model for life span determination in Caenorhabditis elegans. Developmental Cell. 5; 197-203 (2003).
30. Widberg C.H., Bryant N.J., Girotti M., Rea S., James D.E.. Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. J. Biol. Chem. Sep 12; 278 (37): 35093-101. (2003).
31. Morrow I.C., Rea S., Martin S., Prior I.A., Prohaska R., Hancock J.F., James D.E., Parton R.G.. Flotillin-1/reggie-2 Traffics to Surface Raft Domains via a Novel Golgi-independent Pathway: Identification of a Novel Membrane Targeting Domain and a role for Palmitoylation. J. Biol. Chem. 277(50): 48834-41 (2002).
32. Rea S., CLK-1/Coq7p is a DMQ Mono-oxygenase and a New Member of the Di-iron Carboxylate Protein Family. FEBS Letters, 509 : 389-394 (2001).
33. Hekimi, S., Bernard, C., Branicky, R., Burgess, J., Hihi, A., Rea, S. Why Only Time Will Tell. Mech. Aging Dev. 122 (7): 571-594. (2001)
34. Dermine J-F., Duclos S., Garin J., St-louis F., Rea S., Parton RG., Desjardins M. Flotillin-1 Enriched Lipid Raft Domains Accumulate on Maturing Phagosomes. J. Biol. Chem. 276 (21): 18507-12 (2001).
35. Zeng Q., Subramaniam V.N., Wong S.H., Tang B.L., Parton R.G., Rea S., James D.E, Hong W. A Novel Synaptobrevin/VAMP Homologous Protein (VAMP5) is Increased during In Vitro Myogenesis and Present in the Plasma Membrane. Mol. Biol. Cell. 9 (9):2423-2437 (1998).
36. Rea S., Martin L.B., McIntosh S., Macaulay S.L., Ramsdale T., Baldini G., James D.E. Syndet, an adipocyte target SNARE involved in the insulin-induced translocation of GLUT4 to the cell surface. J. Biol. Chem . 273 (30):18784-18792 (1998).
37. Macaulay S.L., Rea S., Gough K.H., Ward C.W., James D.E. Botulinum E toxin light chain does not cleave SNAP-23 and only partially impairs insulin stimulation of GLUT-4 translocation in 3T3-L1 cells. Biochem. Biophys. Res. Commun. 237 (2):388-393 (1997).
38. Rea S., James D.E. Moving GLUT4: the Biogenesis and Trafficking of GLUT4 Storage Vesicles. Diabetes 46 (11):1667-1677. (1997).
39. Muscat G.E., Rea S., Downes M. Identification of a regulatory function for an orphan receptor in muscle: COUP-TF II affects the expression of the MyoD gene family during myogenesis. Nucl. Acids Res. 23 (8):1311-1318. (1995).
