The Table below is a compilation of published mutational data on WRN mutations that have been identified in Werner syndrome patients. The different designations of individual mutations are cross-referenced, mutations and their consequences indicated, and original sources identified for each mutation.
For additional information on each mutation, please click on the NWG mutation designation, which will take you to a mutation-specific page that contains additional information.
| New Working Group Mutation Designation* | OMIM | HGMD | Japan # | Nuc. Change | AA Change | Source |
| c.733-734delAA | -- | CD972512 | 10 | del AA | fs>TER | 1 |
| c.1336C>T | -- | CD961463 | 6 | C>T | ARG>TER | 2 |
| c.1396delA | 277700.0006 | CD962189 | -- | del A | fs>TER | 2,3 |
| c.1509-1510insATCT | 277700.0008 | CI962367 | -- | ins ATCT | fs>TER | 2 |
| c.1602T>A | -- | CM971590 | 9 | T>A | TYR>TER | 1 |
| c.2320-3056del | -- | No # | -- | >15kb del | fs>TER | 2,7 |
| c.2319-2320ins105 | -- | No # | -- | -- | Unknown | 2 |
| c.2473C>T | -- | -- | -- | C>T | Gln>TER | 2 |
| IVS20+1G>T | -- | CS971930 | -- | -- | fs>TER | 4 |
| c.2896C>T | -- | CM961464 | -- | C>T | Arg>TER | 2 |
| c.3004delG | -- | CD991940 | -- | del G | fs>TER | 5 |
| c.3259-3262delCAAA | -- | -- | -- | del CAAA | fs>TER | 6 |
| 3265-3266delGA | -- | -- | -- | del GA | fs>TER | 6 |
| IVS25-G>C | 277700.0004 | CS961715 | 4 | -- | fs>TER | 7 |
| IVS26+1G>C | -- | CS991526 | -- | -- | fs>TER | 6 |
| IVS28+1G>T | -- | CS961716 | -- | -- | fs>TER | 2 |
| c.3677delA | -- | CD962190 | 7 | del A | fs>TER | 1 |
| IVS29-7T>A | -- | CS979131 | 8 | -- | fs>TER | 1 |
| c.3724C>T | 277700.0002 | CM961465 | 2 | C>T | Gln>TER | 7 |
| IVS30+2T>A | -- | CS961717 | -- | -- | fs>TER | 2,3 |
| Complex | 277700.0003 | CD962191 | 3 | -- | fs>TER | 2,7 |
| c.4144C>T | 277700.0001 | CM961466 | 1 | C>T | Arg>TER | 7 |
| c.4146-4147insA | 277700.0005 | CI972726 | 5 | ins A | fs>TER | 8 |
| Record in Progress | -- | -- | 20 | -- | -- | 9 |
*NWG designations place each WRN mutation in a common descriptive format that is referenced to the human WRN open reading frame sequence, as recommended by the New Working Group on Human Gene Mutation Nomenclature (see Antonarakis, SE and the Nomenclature Working Group (1998). Recommendations for a nomenclature system for human gene mutations. Human Mutation 11:1-3).